{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:48:57Z","timestamp":1775886537505,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018262","name":"Intercept Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018262","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021817","name":"Knud og Edith Eriksens Mindefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Primary biliary cholangitis (PBC) is an autoimmune liver disease whose effect on long\u2010term survival remains unclear. We aimed to compare the prognosis of patients with biopsy\u2010confirmed PBC with population comparators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used nationwide healthcare registries to include all Danish patients diagnosed with histologically confirmed PBC in 1998\u20132020. We estimated the prevalence of PBC and the incidence in 2016\u20132019. Dividing PBC by presence or absence of cirrhosis, we used the cumulative incidence function to estimate the risk of death and HCC. We included 5:1 age\u2010 and sex\u2010matched population comparators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 1163 PBC patients (88.1% women, median age at diagnosis\u2009=\u200959.7\u2009years); those with cirrhosis were older (median 63.9 vs. 59.0). Patients had more comorbidity at diagnosis than comparators, especially connective tissue disease. On January 1st 2021, the prevalence of PBC was 22.3 per 100,000 population. The incidence rate in 2016\u20132019 was 2.80 (95% CI: 2.58\u20133.02) per 100,000 population per year. PBC patients with cirrhosis had a higher 10\u2010year risk of death than their matched comparators, adjusted relative risk\u2009=\u20092.41 (95% CI: 1.89\u20133.09). For patients with non\u2010cirrhotic PBC, the 10\u2010year risk of death was 18.5% (95% CI: 15.5\u201321.7) versus 14.3% (95% CI: 13.0\u201315.6) for their comparators, adjusted relative risk\u2009=\u20091.22 (95% CI: 1.03\u20131.47). Patients with cirrhotic PBC had a 10\u2010year risk of HCC at 2.6% (95% CI: 0.8\u20136.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with PBC have a worse prognosis than the general population irrespective of the presence or absence of cirrhosis at the time of PBC diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70610","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:45:21Z","timestamp":1773812721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Biliary Cholangitis Increases Mortality Irrespective of Presence or Absence of Cirrhosis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-4500","authenticated-orcid":false,"given":"Lars","family":"Bossen","sequence":"first","affiliation":[{"name":"Department of Hepatology &amp; Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Internal Medicine Horsens Regional Hospital  Horsens Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Hepatology &amp; Gastroenterology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Hepatology &amp; Gastroenterology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Hepatology &amp; Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00154-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15329"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432479"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16023"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290603"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15533"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15583"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47890-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260508"},{"key":"e_1_2_11_12_1","first-page":"263","article-title":"The Danish National Hospital Register. A Valuable Source of Data for Modern Health Sciences","volume":"46","author":"Andersen T. 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