{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:14:06Z","timestamp":1783430046698,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL163486"],"award-info":[{"award-number":["K23HL163486"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK139189"],"award-info":[{"award-number":["R01DK139189"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Although pregnant people are a WHO priority population for hepatitis C (HCV) elimination, there is limited guidance on HCV treatment in pregnancy. Emerging data suggests direct acting antiviral (DAA) therapy is safe and effective. We performed a multinational survey among gastro\u2010hepatologists (GI\u2010Hep), infectious disease (ID) specialists, obstetricians\u2010gynaecologists (ob\u2010gyns), and general practitioners (GP) to evaluate current perspectives on HCV treatment in pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 39\u2010item survey was designed by experts at The Global Liver Council, the American College of Obstetricians and Gynaecologists, and the Coalition for Global Hepatitis Elimination and distributed electronically. Survey responses were compared across medical specialties and regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 651 participants from all WHO regions representing 58 countries completed the survey: GI\u2010Hep: 46%, GP\u2010ID: 36%, ob\u2010gyns: 18%. Only 25% would consider treating HCV during pregnancy, with significant differences by specialty. Main reasons for not considering DAAs in pregnancy were insufficient safety data (27%) and no clear guidelines for HCV treatment (32%). The highest acceptance of DAA use in pregnancy was in North America (45% vs. &lt;\u200920% in other regions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01)). Predictors of a greater willingness to treat HCV in pregnancy were having \u2265\u200910% of practice population with injection drug use (aOR: 2.31; 95% CI: 1.49\u20133.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002). GI\u2010Hep specialty was associated with a lower willingness (aOR: 0.47; 95% CI: 0.28\u20130.78;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite relatively high levels of HCV knowledge, few participants have experience with HCV treatment in pregnancy or would consider such treatment. Further availability of safety evidence and the inclusion of specific recommendations in guidelines could increase uptake of DAAs for pregnant individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70619","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T07:10:46Z","timestamp":1775459446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physician Perspectives on Hepatitis C Treatment During Pregnancy: A Multinational Multispecialty Survey"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-6253","authenticated-orcid":false,"given":"Tatyana","family":"Kushner","sequence":"first","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Division of Gastroenterology &amp; Hepatology Weill Cornell Medicine  New York New York USA"},{"name":"Division of Obstetrics &amp; Gynecology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Buti","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Liver Unit, Hospital Universitari Vall d Hebron and CIBEREHD del Instituto Carlos III Universidad Autonoma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-6894","authenticated-orcid":false,"given":"Mohamed","family":"El\u2010Kassas","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Endemic Medicine Department, Faculty of Medicine Helwan University  Cairo Egypt"},{"name":"Applied Science Research Center Applied Science Private University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-5283","authenticated-orcid":false,"given":"Yusuf","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Department of Gastroenterology, School of Medicine Recep Tayyip Erdo\u011fan University  Rize T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Division of Metabolism and Endocrinology, Department of Hepatology, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-5736","authenticated-orcid":false,"given":"Yuichiro","family":"Eguchi","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Liver Center of Saga University Hospital  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart K.","family":"Roberts","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Alfred Hospital Gastroenterology Department Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wah\u2010Kheong","family":"Chan","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Gastroenterology and Hepatology Unit, Department of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-1900","authenticated-orcid":false,"given":"Ming\u2010Lung","family":"Yu","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Center of Hepatitis Research, College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponsiano","family":"Ocama","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Department of Medicine Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira","family":"Khaderi","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manida","family":"Wungjiranirun","sequence":"additional","affiliation":[{"name":"The Global Liver Council Center for Outcomes Research in Liver Disease  Washington District of Columbia USA"},{"name":"Division of Gastroenterology &amp; 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