{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:13:47Z","timestamp":1783430027879,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Despite the aggressive nature of paediatric autoimmune hepatitis (P\u2010AIH), population\u2010based epidemiology is poorly described. We aimed to validate an algorithm to identify patients with P\u2010AIH in the Danish National Patient Registry (DNPR) and report incidence rates, prevalence, and describe medication exposure and liver transplantation rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a nationwide, register\u2010based study. We used a smaller population\u2010based P\u2010AIH cohort as true positives for validation. The best\u2010performing algorithm was then used to identify all patients in Denmark with P\u2010AIH (1978\u20132022). Incidence rates and prevalence for the period 1996\u20132022 are presented. We used the National Prescription Register and DNPR to report on the use of prednisolone, thiopurine, and tacrolimus as well as liver transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Based on the best\u2010performing algorithm (sensitivity 0.94, specificity 1.0), we identified 222 incident patients. The incidence rate rose from 0.7\/100000 person\u2010years in 1999\u20132001 to the highest observed incidence rate in 2014\u20132016 (4.5\/100000 person\u2010years). The prevalence rose from 2.2\/100.000 persons in 1999\u20132001 to the highest observed in the 2017\u20132019 period (8.8\/100.000 persons). During the first year, 212 (95%) were treated with prednisolone, 159 (72%) with thiopurines, and 23 (10%) with tacrolimus. After five years, 219 (99%) had been treated with prednisolone, 178 (80%) with thiopurines, and 44 (20%) with tacrolimus. Native liver survival was 97% and 93% at 5 and 10\u2009years after diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence and prevalence of paediatric autoimmune hepatitis in Denmark have increased over the past two decades. Most patients receive corticosteroids and thiopurines, and native liver survival remains high.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70625","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:41:59Z","timestamp":1774590119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence, Prevalence, Medication Use, and Transplant Rates in Paediatric Autoimmune Hepatitis\u2014A Nationwide Cohort Study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6956-7676","authenticated-orcid":false,"given":"Mikkel","family":"Malham","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"},{"name":"Copenhagen Centre for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"},{"name":"Child Life and Health, Centre for Inflammation Research, University of Edinburgh  Edinburgh UK"},{"name":"Department of Pediatric Gastroenterology and Nutrition Royal Hospital for Children and Young People  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"},{"name":"Copenhagen Centre for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fie Brantbjerg","family":"Tinning","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iben M\u00f8ller","family":"J\u00f8nsson","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Wewer","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"},{"name":"Copenhagen Centre for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital \u2013 Amager and Hvidovre  Hvidovre Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Henderson","sequence":"additional","affiliation":[{"name":"Child Life and Health, Centre for Inflammation Research, University of Edinburgh  Edinburgh UK"},{"name":"Department of Pediatric Gastroenterology and Nutrition Royal Hospital for Children and Young People  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne H\u00f8rby","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen 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