{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:13:51Z","timestamp":1783430031010,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Portal vein thrombosis (PVT) is a common sequela of cirrhosis. Despite regression of fibrosis\/cirrhosis observed among some patients after disease\u2010specific treatment, few studies have considered the role of treatment and response on risk of PVT among patients with cirrhosis across different liver disease states. We considered aetiological treatment and response as well as whether non\u2010selective beta\u2010blockers (NSBBs), statins, and anticoagulants were associated with risk of PVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data for patients with cirrhosis (compensated or decompensated) from two large, US\u2010based multisite cohort studies. Patients with hepatitis C (HCV) were drawn from the Chronic Hepatitis Cohort Study. Patients with primary biliary cholangitis (PBC) were drawn from the Fibrotic Liver Disease Consortium. Risk for PVT was assessed using a discrete survival model that includes both fixed covariates and time\u2010dependent variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 6659 HCV patients, 274 developed PVT across ~13\u2009years of follow\u2010up. Significant risk factors included time\u2010varying decompensated cirrhosis (adjusted hazard ratio [aHR] 27.41, 95% confidence interval [CI] 15.89\u201347.30), male sex (aHR 1.48, 95% CI 1.12\u20131.94), and use of NSBBs (aHR 2.07, 95% CI 1.61\u20132.67). Among 786 PBC patients, 67 developed PVT across ~8\u2009years of follow\u2010up. Use of NSBBs was the only significant PVT risk factor in these patients (aHR 2.56, 95% CI 1.52\u20134.31). Neither sustained virological response [SVR] after antiviral treatment (HCV patients) nor response to ursodeoxycholic acid [UDCA] treatment (PBC patients) was associated with risk of PVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In two large well\u2010characterized samples of cirrhotic patients with HCV or PBC, disease\u2010specific treatments were not associated with PVT risk. NSBB treatment was independently associated with &gt;\u20092 times the risk of PVT in both samples, regardless of compensated or decompensated status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70628","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:45:06Z","timestamp":1775281506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Disease\u2010Specific Treatment and Non\u2010Selective Beta Blockers on Risk of\n                    <scp>PVT<\/scp>\n                    in Cirrhotic Patients With\n                    <scp>HCV<\/scp>\n                    or\n                    <scp>PBC<\/scp>"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-1846","authenticated-orcid":false,"given":"Humberto C.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Henry Ford Health  Detroit Michigan USA"},{"name":"School of Medicine Wayne State University  Detroit Michigan USA"},{"name":"College of Human Medicine Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8666-3849","authenticated-orcid":false,"given":"Stuart C.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Henry Ford Health  Detroit Michigan USA"},{"name":"School of Medicine Wayne State University  Detroit Michigan USA"},{"name":"College of Human Medicine Michigan State University  East Lansing Michigan USA"},{"name":"Center for Health Policy and Health Services Research Henry Ford Health  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheri","family":"Trudeau","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trueman","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lora","family":"Rupp","sequence":"additional","affiliation":[{"name":"Center for Health Policy and Health Services Research Henry Ford Health  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Melkonian","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Center for Health Research Kaiser Permanente Northwest  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihe G.","family":"Daida","sequence":"additional","affiliation":[{"name":"Center for Integrated Health Care Research Kaiser Permanente Hawaii  Honolulu Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep K.","family":"Sahota","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation Kaiser Permanente Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Bowlus","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Human Medicine Michigan State University  East Lansing Michigan USA"},{"name":"Department of Public Health Sciences Henry Ford Health  Detroit Michigan 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