{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:13:51Z","timestamp":1783430031025,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001821","name":"Vienna Science and Technology Fund","doi-asserted-by":"publisher","award":["VRG15\u2010005"],"award-info":[{"award-number":["VRG15\u2010005"]}],"id":[{"id":"10.13039\/501100001821","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001821","name":"Vienna Science and Technology Fund","doi-asserted-by":"publisher","award":["NXT 19\u2010008"],"award-info":[{"award-number":["NXT 19\u2010008"]}],"id":[{"id":"10.13039\/501100001821","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016168","name":"Ludwig Boltzmann Gesellschaft","doi-asserted-by":"publisher","award":["LBG_KFG:22:32"],"award-info":[{"award-number":["LBG_KFG:22:32"]}],"id":[{"id":"10.13039\/501100016168","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FRMEQU202303016287"],"award-info":[{"award-number":["FRMEQU202303016287"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["ATIP AVENIR"],"award-info":[{"award-number":["ATIP AVENIR"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>To develop and validate a CT\u2010based radiomics model to assess HVPG and predict a composite endpoint of liver\u2010related events (LRE: decompensation and liver\u2010related death) in patients with cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 357 cirrhosis patients, who received invasive HVPG measurements, 120 liver\u2010healthy controls (training cohort) and 85 and 100 cirrhosis patients (internal and external validation cohorts, respectively), and contrast\u2010enhanced abdominal CTs. After volumetric segmentation of the liver and spleen on CT, Bayesian parameter optimization was used for selection of extracted features and hyperparameter tuning in random forest or elastic net models. Prediction accuracy was evaluated using Pearson correlation coefficients of predicted (\u2019radio\u2010HVPG\u2019) and invasive HVPG. Discrimination between relevant HVPG cut\u2010offs was determined by receiver operating characteristic (ROC) analysis. The predictive value of radio\u2010HVPG and invasive\u2010HVPG for LRE was compared using Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Radio\u2010HVPG, predicted by an optimized random forest model based on 74 selected CT features, correlated with invasive\u2010HVPG and detected clinically significant portal hypertension (CSPH: HVPG \u2265\u200910\u2009mmHg) on the internal (Pearson\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.63, AUC 0.89 [95% CI: 0.81\u20130.96]) and external (Pearson\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.62, AUC 0.80 [95% CI: 0.64\u20130.91]) validation cohorts. Radio\u2010HVPG predicted LRE when adjusting for MELD and albumin (adjusted HR: 1.14 [95% CI: 1.04\u20131.25],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and performed similarly to invasive\u2010HVPG.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Radiomic features accurately predict HVPG in patients with cirrhosis and allow risk stratification for LRE in a radiomics\u2010clinical signature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70633","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:37:02Z","timestamp":1775540222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Radiomics\u2010Based Assessment of Portal Hypertension Severity and Risk Stratification of Cirrhotic Patients Using Routine\n                    <scp>CT<\/scp>\n                    Scans"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4975-4618","authenticated-orcid":false,"given":"Celine","family":"Sin","sequence":"first","affiliation":[{"name":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences  Vienna Austria"},{"name":"Max Perutz Labs  Vienna Austria"},{"name":"University of Vienna Center for Molecular Biology, Department of Structural and Computational Biology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Luther","family":"Watzenboeck","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"},{"name":"Clinical Research Group MOTION Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Iofinova","sequence":"additional","affiliation":[{"name":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences  Vienna Austria"},{"name":"Institute of Science and Technology Austria  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-3061","authenticated-orcid":false,"given":"Lorenz","family":"Balcar","sequence":"additional","affiliation":[{"name":"Clinical Research Group MOTION Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Christian Doppler Laboratory for Portal Hypertension and Liver Fibrosis Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-166X","authenticated-orcid":false,"given":"Georg","family":"Semmler","sequence":"additional","affiliation":[{"name":"Clinical Research Group MOTION Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Scheiner","sequence":"additional","affiliation":[{"name":"Clinical Research Group MOTION Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna 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Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Moga","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Beaujon Service d'H\u00e9patologie, DMU DIGEST, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE\u2010LIVER  Clichy France"},{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Inserm, Centre de Recherche sur l'Inflammation, UMR 1149  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Emmanuel","family":"Rautou","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Beaujon Service d'H\u00e9patologie, DMU DIGEST, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE\u2010LIVER  Clichy France"},{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Inserm, Centre de Recherche sur l'Inflammation, UMR 1149  Paris 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