{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:23:57Z","timestamp":1792103037456,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/01345"],"award-info":[{"award-number":["PI22\/01345"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["GLD24\/25635"],"award-info":[{"award-number":["GLD24\/25635"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FORT23\/00008"],"award-info":[{"award-number":["FORT23\/00008"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI25\/01825"],"award-info":[{"award-number":["PI25\/01825"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>One third of patients with cirrhosis experience an early readmission, and predicting such an event is challenging. We developed and validated a scoring system to predict non\u2010elective readmissions in patients with cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational and multicenter retrospective study enrolled 1382 consecutive non electively admitted patients with cirrhosis and acute decompensation from 20 centers in Spain and were categorized as derivation and validation cohorts. The cohorts were followed for 90\u2009days after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The rate of 7\u2010day, 30\u2010day and 90\u2010day readmission was 5.3%, 19.9% and 36.7%, respectively, while 12.3% of patients died during the study. History of decompensation [HR 1.31 (95% CI 1.04\u20131.64);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022], Charlson index [HR 1.08 (95% CI 1.02\u20131.14);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012], large\u2010volume paracentesis [HR 1.37 (95% CI 1.09\u20131.73);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007], INR [HR 1.52 (95% CI 1.17\u20131.97);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001] and bilirubin [HR 1.03 (95% CI 1.001\u20131.05);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045] at prior discharge were associated with early readmission. REACT score distinguished patients at high versus low risk of readmission: (a) derivation cohort 19.6% vs. 0% for 7\u2010day, 70.6% vs. 2.5% for 30\u2010day, 91.1% vs. 20.2% for 90\u2010day; (b) internal validation 20.6% vs. 0% for 7\u2010day, 58.8% vs. 0.5% for 30\u2010day, 72.1% vs. 11.8% for 90\u2010day; (c) external validation 5.8% vs. 0% for 7\u2010day, 24.6% vs. 0% for 30\u2010day, 44.2% vs. 12% for 90\u2010day. Also, high\u2010risk patients were more likely to be readmitted before their scheduled follow\u2010up appointment (51.9% vs. 5.7%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cirrhosis readmission rate was 20% within the first 30\u2009days after discharge. REACT score effectively predicted the risk of non\u2010elective readmission in patients with decompensated cirrhosis. Prospective studies are needed to fully assess the usefulness of this scoring system in predicting non\u2010elective readmissions and in developing strategies to prevent them.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70639","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:39:43Z","timestamp":1776231583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["REACT Score, a Novel Scoring System, Improves the Prediction of Non\u2010Elective Readmissions in Patients With Decompensated Cirrhosis"],"prefix":"10.1111","volume":"46","author":[{"given":"Yolanda","family":"S\u00e1nchez\u2010Torrijos","sequence":"first","affiliation":[{"name":"Hospital Universitario Virgen del Roc\u00edo  Sevilla Spain"},{"name":"Instituto de Biomedicina de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Torres\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Costal del Sol  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Carmona","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen Macarena  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ib\u00e1\u00f1ez\u2010Samaniego","sequence":"additional","affiliation":[{"name":"Hospital Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Casado","sequence":"additional","affiliation":[{"name":"Hospital Universitario Torrec\u00e1rdenas  Almer\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Garc\u00eda\u2010Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Victoria  M\u00e1laga Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina\u2010IBIMA. 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