{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:50:47Z","timestamp":1785801047779,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RC2026\/105_01"],"award-info":[{"award-number":["RC2026\/105_01"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Dual immune checkpoint blockade with tremelimumab plus durvalumab (STRIDE) is an established first\u2010line therapy for unresectable hepatocellular carcinoma (uHCC); however, real\u2010world evidence on its safety, toxicity kinetics and liver function dynamics remains limited. We aimed to evaluate the tolerability and on\u2010treatment changes in hepatic function and effectiveness in a multicentre cohort of patients treated with STRIDE in routine practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of prospectively collected data from 115 consecutive patients with uHCC treated with STRIDE across 12 centres in Lombardy, Italy. Clinical, biochemical and radiological variables were recorded at baseline and throughout the therapy. Adverse events were graded per CTCAE v5.0, and Child\u2013Pugh was used to assess hepatic functional evolution. The temporal toxicity patterns were evaluated using smoothed hazard functions. Progression\u2010free survival (PFS), overall survival (OS) and competing\u2010risk cumulative incidences of progression and death were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow\u2010up was 8.9\u2009months. More than 80% of the adverse events occurred within the first 2\u2009months, and severe toxicities were infrequent. Child\u2013Pugh deterioration from class A to B occurred in 7.8% of patients from baseline to day 28, increasing to 12.1% by day 56. PFS was 5.7\u2009months; the median OS was not reached, with OS rates of 78.2% at 6\u2009months and 53.3% at 18\u2009months. Progression was the predominant early event, with a cumulative incidence of 49.2% at 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In routine clinical practice, STRIDE shows reproducible effectiveness and a manageable safety profile, with an early and stabilising incidence of adverse events. Dynamic assessment of liver function shows that hepatic function declines modestly but is still clinically meaningful in affected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70640","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:58:10Z","timestamp":1776409090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Durvalumab\u2013Tremelimumab in Advanced Hepatocellular Carcinoma: Real\u2010World Data From the\n                    <scp>LOR<\/scp>\n                    \u2010\n                    <scp>HCC<\/scp>\n                    (Lombardy Real\u2010World\n                    <scp>HCC<\/scp>\n                    Group)"],"prefix":"10.1111","volume":"46","author":[{"given":"Andrea","family":"Casadei\u2010Gardini","sequence":"first","affiliation":[{"name":"Department of Oncology Vita\u2010Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Canova","sequence":"additional","affiliation":[{"name":"Division of Hepatology San Giuseppe Hospital, IRCCS MultiMedica  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Tosi","sequence":"additional","affiliation":[{"name":"The Falck Division of Medical Oncology, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Camera","sequence":"additional","affiliation":[{"name":"Department of Oncology Vita\u2010Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bocchero","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Humanitas Cancer Center, IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Pozzoni","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Department of Medicine, Alessandro Manzoni Hospital, ASST Lecco  Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Torchio","sequence":"additional","affiliation":[{"name":"U.O.C. Oncologia Medica, ASST Santi Paolo e Carlo, Ospedale San Carlo Borromeo  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Corallo","sequence":"additional","affiliation":[{"name":"SC Oncology Unit, IRCCS Foundation, San Matteo Hospital  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Costantino","sequence":"additional","affiliation":[{"name":"Department of Organ Failure and Transplantation, Gastroenterology, Hepatology and Liver Transplantation Ospedale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Stagno","sequence":"additional","affiliation":[{"name":"SC Medical Oncology, Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Grizzi","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology ASST Cremona  Cremona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Gengarle","sequence":"additional","affiliation":[{"name":"Complex Medical Oncology Unit, ASST Mantova, Carlo Poma Hospital  Mantova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Tomasello","sequence":"additional","affiliation":[{"name":"Department of Oncology ASST Ospedale Maggiore di Crema  Crema Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Ansarin","sequence":"additional","affiliation":[{"name":"Department of Oncology ASST Ospedale Maggiore di Crema  Crema Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Bruccoleri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Bencardino","sequence":"additional","affiliation":[{"name":"The Falck Division of Medical Oncology, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3600-0232","authenticated-orcid":false,"given":"Mara","family":"Persano","sequence":"additional","affiliation":[{"name":"Department of Oncology Vita\u2010Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Pino","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Humanitas Cancer Center, IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Riva","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Department of Medicine, Alessandro Manzoni Hospital, ASST Lecco  Lecco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Vavassori","sequence":"additional","affiliation":[{"name":"Medicina Ad Indirizzo Epatologico e Gastroenterologia, ASST Santi Paolo e Carlo, Ospedale San Paolo  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Argiento","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Mazzarelli","sequence":"additional","affiliation":[{"name":"Hepatology &amp; 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