{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:33:36Z","timestamp":1790616816099,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>GLP\u20101 receptor agonists (GLP\u20101RAs) promote significant weight loss, but their impact on muscle mass, strength, and quality in metabolic dysfunction\u2013associated steatotic liver disease (MASLD), a condition prone to muscle impairment, remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review of MEDLINE\/PubMed, Embase, and the Cochrane Library up to 2 December 2025. Interventional and observational studies assessing GLP\u20101RA therapy and muscle\u2010related outcomes in adults with MASLD were included. Muscle mass was assessed by computed tomography or magnetic resonance imaging, dual\u2010energy X\u2010ray absorptiometry, or bioelectrical impedance analysis; lean mass and fat\u2010free mass were considered proxies. Muscle strength was evaluated using handgrip strength (HGS) or sit\u2010to\u2010stand (STS) tests. Muscle quality was assessed by imaging\u2010based quantification of intramuscular fat infiltration (myosteatosis) or functionally based on performance relative to muscle mass. Results were synthesised narratively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve studies were included (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009810). Eleven assessed muscle mass (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009785) across different GLP\u20101RA regimens and treatment durations (12\u201352\u2009weeks). Findings suggested relative preservation of muscle mass, with modest reductions generally proportional to overall weight loss. Muscle strength was evaluated in three studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009477), with no evidence of deterioration in HGS or STS performance despite meaningful weight loss. Muscle quality was assessed in four studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009139) using imaging or functional metrics, with results suggesting preserved or improved muscle quality. Evidence was limited by small sample sizes and heterogeneous assessment methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence suggests that GLP\u20101RA therapy is not associated with clinically meaningful loss of muscle mass or strength in adults with MASLD, with early data indicating possible improvements in muscle quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70643","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:25:04Z","timestamp":1776489904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists on Muscle Mass, Strength, and Quality in\n                    <scp>MASLD<\/scp>\n                    : A Systematic Review"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-9323","authenticated-orcid":false,"given":"Fernando","family":"Iorra","sequence":"first","affiliation":[{"name":"Postgraduate Program in Medical Sciences: Endocrinology Universidade Federal Do Rio Grande Do Sul  Porto Alegre Brazil"},{"name":"Faculty of Medicine, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Jayakar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Yee","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Metabolic Medicine, St Mary's Hospital Imperial College NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Thursz","sequence":"additional","affiliation":[{"name":"Faculty of 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