{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:04:36Z","timestamp":1781183076694,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CH 288\/6\u20102"],"award-info":[{"award-number":["CH 288\/6\u20102"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Polymorphisms of group VIA calcium\u2010independent phospholipase A2 (iPLA2\u03b2 or PLA2G6) are associated with Type\u20102 diabetes, blood lipids and inflammation. Global deficiency in iPLA2\u03b2\u2010null mice elicited protection against hepatic steatosis but not hepatic inflammation after high\u2010fat diet (HFD) feeding. We aimed to determine whether HFD\u2010induced phenotypes could be affected by PLA2G6 deficiency specifically in myeloid cells and hepatocytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male control Pla2g6\n                      <jats:sup>flox\/flox<\/jats:sup>\n                      , myeloid\u2010(Pla2g6\n                      <jats:sup>M\u2212\/\u2212<\/jats:sup>\n                      ) and hepatocyte\u2010(Pla2g6\n                      <jats:sup>Hep\u2212\/\u2212<\/jats:sup>\n                      ) specific Pla2g6\u2010deficient mice were subjected to chow or HFD feeding for 6\u2009months. The contents of phospholipids, white blood cell counts, plasma cytokines and metabolic parameters were quantified. Hepatic inflammation, lymphopoiesis and fibrosis were evaluated by histology, immunohistochemistry, Western blot and qRT\u2010PCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Increased levels of phospholipids were observed in bone marrow\u2010derived macrophages and livers from chow\u2010fed Pla2g6\n                      <jats:sup>M\u2212\/\u2212<\/jats:sup>\n                      and Pla2g6\n                      <jats:sup>Hep\u2212\/\u2212<\/jats:sup>\n                      mice, respectively. After HFD feeding, Pla2g6\n                      <jats:sup>M\u2212\/\u2212<\/jats:sup>\n                      mice displayed a further increase in hepatic recruitment of granulocytes and lymphocytes, plasma cytokines\/lipids, liver inflammation\/fibrosis as well as metabolic parameters including plasma lipoproteins, plasma\/liver lipopolysaccharides, liver triglycerides\/non\u2010esterified free fatty acids, plasma insulin\/leptin and HOMA\u2010IR. These metabolic parameters were further increased in HFD\u2010fed Pla2g6\n                      <jats:sup>Hep\u2212\/\u2212<\/jats:sup>\n                      mice; however, they were protected from hepatic programmed cell death and inflammatory fibrosis with attenuation of plasma lipids and cytokines. Remarkably, these metabolic parameters were also increased in both mutants under chow.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Myeloid\u2010 and hepatocyte\u2010PLA2G6 deficiency elicited aggravation and protection against HFD\u2010induced hepatic inflammation, respectively. However, PLA2G6 deficiency in both cell types exacerbated insulin resistance. PLA2G6 inactivation specifically in hepatocytes may provide a potential therapy option to alleviate diet\u2010induced liver inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70679","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:33:26Z","timestamp":1778243606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct Roles of Myeloid\u2010 and Hepatocyte\u2010PLA2G6 Deletion in Mice With Metabolic Dysfunction\u2010Associated Steatotic Liver Disease"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1130-179X","authenticated-orcid":false,"given":"Gang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Internal Medicine IV University Hospital Heidelberg  Heidelberg Germany"},{"name":"Department of Gastrointestinal Surgery Union Hospital, Tongji Medical College, Huazhong University of Science 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