{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:03:44Z","timestamp":1781258624018,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003107","name":"Bundesministerium f\u00fcr Gesundheit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014690","name":"Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010215","name":"Deutsche Diabetes Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010215","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n People with type 1 diabetes feature lower concentrations of hepatic adenosine\u2010triphosphate (ATP) and inorganic phosphate (Pi), which further decline during the early course of disease. However, it is unknown whether inflammatory pathways are involved in the diabetes\u2010associated alterations of hepatic energy metabolism. Participants (median age 35\u2009years, BMI 21.7\u2009kg\/m\n 2<\/jats:sup>\n , HbA1c 6.0%) of the German Diabetes Study (GDS) with short type 1 diabetes duration (\u2264\u20095\u2009years) underwent\n 1<\/jats:sup>\n H\/\n 31<\/jats:sup>\n P magnetic resonance spectroscopy to quantify hepatic lipid content, \u03b3ATP and Pi concentrations. Inflammatory proteins in serum and in supernatants of stimulated CD4\n +<\/jats:sup>\n and CD8\n +<\/jats:sup>\n T cells were measured by a multiplex assay (OLINK Target 96 Inflammation). Analyses were adjusted for multiple testing with false discovery rate (FDR)\u2010correction. Hepatic \u03b3ATP concentrations positively correlated with circulating TNFSF14 (\n r<\/jats:italic>\n \u2009=\u20090.98,\n p<\/jats:italic>\n \u2009<\u20090.001,\n p<\/jats:italic>\n FDR<\/jats:sub>\n \u2009=\u20090.009) and MMP10 (\n r<\/jats:italic>\n \u2009=\u20090.71,\n p<\/jats:italic>\n \u2009=\u20090.047). Hepatic Pi was positively associated with circulating MMP10 (\n r<\/jats:italic>\n \u2009=\u20090.90,\n p<\/jats:italic>\n \u2009=\u20090.002), with CD4\n +<\/jats:sup>\n T cell responses, particularly CCL3 (\n r<\/jats:italic>\n \u2009=\u20090.74,\n p<\/jats:italic>\n \u2009=\u20090.010) and CCL4 (\n r<\/jats:italic>\n \u2009=\u20090.75,\n p<\/jats:italic>\n \u2009=\u20090.008), and with CD8\n +<\/jats:sup>\n T cell responses, particularly CCL3 (\n r<\/jats:italic>\n \u2009=\u20090.86,\n p<\/jats:italic>\n \u2009=\u20090.014), CCL4 (\n r<\/jats:italic>\n \u2009=\u20090.96,\n p<\/jats:italic>\n \u2009<\u20090.001) and TNFSF14 (\n r<\/jats:italic>\n \u2009=\u20090.89,\n p<\/jats:italic>\n \u2009=\u20090.007). Hepatic lipid content (median 0.4%) negatively correlated with IL\u20102, IL4, IL\u201013 and TNF release from CD8\n +<\/jats:sup>\n T cells (all\n p<\/jats:italic>\n FDR<\/jats:sub>\n <\u20090.05). Even in lean metabolically well\u2010controlled persons with early type 1 diabetes, measures of hepatic energy metabolism strongly associate with a specific inflammatory profile and T cell responses, suggesting a role of pro\u2010inflammatory mechanisms in the regulation of hepatic metabolism, even in the absence of steatotic liver disease.\n <\/jats:p>\n \n Trial Registration:<\/jats:bold>\n ClinicalTrial.gov<\/jats:ext-link>\n identifier: NCT01055093\n <\/jats:p>","DOI":"10.1111\/liv.70693","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:50:07Z","timestamp":1778737807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Inflammation and Peripheral T Cell Responses Associate With Hepatic Energy Metabolism in Recent\u2010Onset Type 1 Diabetes"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-9442","authenticated-orcid":false,"given":"Jacqueline M.","family":"Ratter\u2010Rieck","sequence":"first","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research Partner D\u00fcsseldorf M\u00fcnchen\u2010Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3873-6555","authenticated-orcid":false,"given":"Alexandra","family":"Zepina","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research Partner D\u00fcsseldorf M\u00fcnchen\u2010Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6783-9520","authenticated-orcid":false,"given":"Maximilian","family":"Huttasch","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research Partner D\u00fcsseldorf M\u00fcnchen\u2010Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3032-9096","authenticated-orcid":false,"given":"Yuliya","family":"Kupriyanova","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research Partner D\u00fcsseldorf M\u00fcnchen\u2010Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Petrera","sequence":"additional","affiliation":[{"name":"Metabolomics and Proteomics Core Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Trenkamp","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research Partner D\u00fcsseldorf M\u00fcnchen\u2010Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf 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