{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:46:42Z","timestamp":1782452802556,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014810","name":"Fondazione di Sardegna","doi-asserted-by":"publisher","award":["FDS2019VIDILI"],"award-info":[{"award-number":["FDS2019VIDILI"]}],"id":[{"id":"10.13039\/100014810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgrounds and Aims<\/jats:title>\n                    <jats:p>Ultrasound\u2010based spleen stiffness measurement (SSM) is a valid non\u2010invasive tool to assess portal hypertension (PH) in chronic liver disease. Whereas the role of the respiratory phase during liver stiffness measurements is established, no study has specifically addressed how respiration influences SSM by transient elastography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the influence of respiration on SSM assessed with FibroScan 630 (Echosens, Paris, France).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty\u2010three patients with chronic liver disease of different aetiologies underwent SSM using vibration\u2010controlled transient elastography (VCTE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SSM acquired during a normal respiratory cycle showed better diagnostic accuracy than measurements obtained during breath\u2010hold after deep inspiration (AUROC 0.835 [95% CI 0.743\u20130.928] vs. 0.798 [95% CI 0.697\u20130.899]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SSM by VCTE should be performed during quiet breathing, as it showed good diagnostic accuracy for predicting the presence of oesophageal varices (OV) in patients with chronic liver disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70714","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:07:11Z","timestamp":1781334431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Breath Holding on Spleen Stiffness Measured by 100\u2009Hz Vibration Controlled Transient Elastography"],"prefix":"10.1111","volume":"46","author":[{"given":"Sebastiana","family":"Atzori","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Azienda Ospedaliero Universitaria di Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Meloni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Azienda Ospedaliero Universitaria di Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7112-5025","authenticated-orcid":false,"given":"Marco","family":"Arru","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Pharmacy University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-5829","authenticated-orcid":false,"given":"Gianpaolo","family":"Vidili","sequence":"additional","affiliation":[{"name":"Department of 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