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Median age was 45\u2009years with 75% female and 78% White. Patients with biologic\u2010DILI were younger, had longer latency (median 124\u2009days), predominantly hepatocellular injury (78%) and mostly mild severity (74%) with no deaths and one chronic case. Immunomodulator\u2010DILI was mainly cholestatic or mixed, with jaundice in 57%; two were fatal, one required transplant and five became chronic. Aminosalicylate\u2010DILI had the shortest latency (median 40\u2009days), was hepatocellular (57%) or cholestatic (36%), often with rash (50%) or pruritus (36%), mostly mild (64%), with two chronic cases. DILI phenotype was similar with IBD and non\u2010IBD indications. Multiple\n                      <jats:italic>HLA<\/jats:italic>\n                      alleles were associated with infliximab (\n                      <jats:italic>HLA\u2010DPB1*01:01<\/jats:italic>\n                      ,\n                      <jats:italic>HLA\u2010B*08:01<\/jats:italic>\n                      and\n                      <jats:italic>HLA\u2010DQB1*02:01<\/jats:italic>\n                      ) azathioprine (\n                      <jats:italic>HLA\u2010DR3<\/jats:italic>\n                      ,\n                      <jats:italic>HLA\u2010DRB1*03:01<\/jats:italic>\n                      and\n                      <jats:italic>HLA\u2010A*33:01)<\/jats:italic>\n                      , mercaptopurine (\n                      <jats:italic>HLA\u2010A*11:01<\/jats:italic>\n                      and\n                      <jats:italic>HLA\u2010B*37:01<\/jats:italic>\n                      ) and sulfasalazine (\n                      <jats:italic>HLA\u2010B*53:01<\/jats:italic>\n                      ) DILI, compared to population controls and other DILI cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Clinical features such as latency, injury pattern, jaundice and dermatologic findings help distinguish implicated agents and guide prognosis in suspected DILI from IBD therapies.\n                      <jats:italic>HLA<\/jats:italic>\n                      alleles may help identify individuals at higher DILI risk and support causality.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70719","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:32:01Z","timestamp":1780464721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Liver Injury From Medications Used for Treating Inflammatory Bowel Disease: The Drug\u2010Induced Liver Injury Network Experience"],"prefix":"10.1111","volume":"46","author":[{"given":"Harish","family":"Gopalakrishna","sequence":"first","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiezhun","family":"Gu","sequence":"additional","affiliation":[{"name":"Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ju","family":"Li","sequence":"additional","affiliation":[{"name":"Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-3439","authenticated-orcid":false,"given":"Huiman","family":"Barnhart","sequence":"additional","affiliation":[{"name":"Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Halegoua\u2010DeMarzio","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert L.","family":"Bonkovsky","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"},{"name":"Advocate Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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