{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:26:36Z","timestamp":1790357196869,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Key Points<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>This study by Colapietro et\u00a0al. [1] demonstrates that the diagnosis of seronegative autoimmune hepatitis is often based on inadequate testing for autoantibodies.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>The best technique to test for autoantibodies in autoimmune liver disease is indirect immunofluorescence on murine triple tissue.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Anti\u2010soluble liver antigen, an autoantibody highly specific for autoimmune hepatitis, is not detected by immunofluorescence but by immunochemical solid phase assays.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>When correct testing for autoantibodies is used, seronegative autoimmune hepatitis is very rare.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Perinuclear anti\u2010neutrophil cytoplasmic antibody (pANNA) can be the only autoantibody present at diagnosis in autoimmune hepatitis and should be tested on a neutrophil substrate by immunofluorescence.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/liv.70735","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:01:04Z","timestamp":1780646464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How Real Is Seronegative Autoimmune Hepatitis?"],"prefix":"10.1111","volume":"46","author":[{"given":"Diego","family":"Vergani","sequence":"first","affiliation":[{"name":"Institute of Liver Studies, MowatLabs, Department of Inflammation Biology, School of Immunology &amp; 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