{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:13Z","timestamp":1787015773628,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502307"],"award-info":[{"award-number":["82502307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752252"],"award-info":[{"award-number":["2024M752252"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aims<\/jats:title>\n Post\u2010TIPS overt hepatic encephalopathy (OHE) and variceal rebleeding (VRB) remain serious complications with limited predictive tools. This study investigates whether the inherent preoperative three\u2010dimensional portal venous geometry (3D\u2010PVG) serves as an independent prognostic biomarker for 1year OHE and VRB in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this multicenter retrospective study, 579 cirrhotic patients undergoing successful TIPS were enrolled. We extracted 3D\u2010PVG features from routine computed tomography angiography (CTA) images before TIPS, quantifying bifurcation angles (\u2018Near\u2019) and vessel segment tortuosity (\u2018Far\u2019). Cox regression identified predictors for 1\u2010year OHE and VRB. Model performance was evaluated using Harrell's C\u2010index, comparing clinical models against integrated clinical\u2010geometric models (3D\u2010CGM).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n For 1\u2010year OHE, increased age (HR 1.458,\n p<\/jats:italic>\n \u2009<\u20090.001), higher BUN (HR 1.171,\n p<\/jats:italic>\n \u2009=\u20090.019), and extremely flat bifurcations (near_bin_87: 172\u00b0\u2013174\u00b0; HR 1.104,\n p<\/jats:italic>\n \u2009=\u20090.039) were independent risk factors. For 1\u2010year VRB, first bleeding (HR 2.347,\n p<\/jats:italic>\n \u2009=\u20090.027), elevated Cr (HR 1.244,\n p<\/jats:italic>\n \u2009=\u20090.012), relatively flat bifurcations (near_bin_74: 146\u00b0\u2013148\u00b0; HR 1.432,\n p<\/jats:italic>\n \u2009=\u20090.001), and very straight vessel segments (far_bin_2: 2\u00b0\u20134\u00b0; HR 1.467,\n p<\/jats:italic>\n \u2009=\u20090.013) were risk factors, while use of covered stents (HR 0.197,\n p<\/jats:italic>\n \u2009=\u20090.013) and gently curved vessel segments (far_bin_27: 52\u00b0\u201354\u00b0; HR 0.262,\n p<\/jats:italic>\n \u2009=\u20090.018) were protective factors. Integrating 3D\u2010PVG features significantly improved predictive performance: the 3D\u2010CGM achieved C\u2010indices of 0.801 for OHE and 0.792 for VRB, surpassing clinical models (0.715 and 0.686, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The inherent portal venous geometry may serve as an independent imaging biomarker for post\u2010TIPS outcomes. The 3D\u2010CGM markedly enhances risk prediction, providing a non\u2010invasive approach for prognosis assessment in portal hypertension.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.70746","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:37:34Z","timestamp":1781336254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Three\u2010Dimensional Portal Vein Geometry Predicts Post\u2010\n TIPS<\/scp>\n \u2010Hepatic Encephalopathy and Variceal Rebleeding: A Multicenter Study"],"prefix":"10.1111","volume":"46","author":[{"given":"Shang","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huaxi MR Research Center (HMRRC) Institute of Radiology and Medical Imaging. West China Hospital of Sichuan University Chengdu Sichuan China"},{"name":"Department of Radiology, Xiamen Key Lab of Psychoradiology and Neuromodulation West China Xiamen Hospital of Sichuan University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology The People's Hospital of Leshan Leshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Center Chongqing University Three Gorges Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanfan","family":"Shi","sequence":"additional","affiliation":[{"name":"Science and Technology Department, Clinical Research Management Office West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijing","family":"Yan","sequence":"additional","affiliation":[{"name":"Clinical Research Centre Sichuan Provincial People's Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6900-0696","authenticated-orcid":false,"given":"Xijiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Research Centre Sichuan Provincial People's Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-2101","authenticated-orcid":false,"given":"Bin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23383"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28906"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-019-02252-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18509"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2011.10.015"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200603000-00001"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18362"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15797"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.12211"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.010"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-022-10344-5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.221648"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015141941"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-334133"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.15141252"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.223201"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.022"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27210"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1385430"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.70133"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07595-5"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i18.3279"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1397"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335123"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-011-0191-6"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.661030"},{"key":"e_1_2_12_30_1","article-title":"Machine Learning Prediction of Hepatic Encephalopathy for Long\u2010Term Survival After Transjugular Intrahepatic Portosystemic Shunt in Acute Variceal Bleeding","volume":"31","author":"Liu D. 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