{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:57:48Z","timestamp":1792612668092,"version":"4.5.0"},"reference-count":137,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is highly prevalent and increasingly recognized as a multisystem cardiometabolic disorder. The global burden, incidence and prognostic implications of coexisting chronic kidney disease (CKD) in MASLD remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this meta\u2010analysis, we searched MEDLINE and EMBASE from inception through September 25, 2025, for observational studies reporting CKD prevalence and\/or incidence among adults (\u2265\u200918\u2009years) with MASLD. The primary outcomes were pooled CKD prevalence, estimated using random\u2010effects models on the logit scale with the Hartung\u2013Knapp adjustment, and pooled CKD incidence (per 1000 person\u2010years), estimated using random\u2010effects models with exact Poisson confidence intervals. Secondary outcomes included all\u2010cause mortality and cardiovascular, renal and cancer outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2811 records, 36 observational studies met the inclusion criteria. Twenty\u2010three studies contributed prevalence estimates (575\u2009615 participants; 56\u2009248 CKD cases) and thirteen studies contributed incidence estimates (27\u2009996 new events). The pooled global CKD prevalence among individuals with MASLD was 15.22% (95% CI 9.69\u201323.12). The pooled CKD incidence was 22.17 per 1000 person\u2010years (95% CI 11.44\u201332.89) in the MASLD population. Hypertension (OR 1.49, 95% CI 1.29\u20131.72), dyslipidaemia (OR 1.22, 95% CI 1.20\u20131.24) and diabetes (OR 1.94, 95% CI 1.69\u20132.22) were associated with higher odds of CKD in the MASLD population. All\u2010cause mortality rates were 18.28 per 1000 person\u2010years (95% CI 3.45\u201333.11) in coexistent MASLD and CKD, more than double those in the MASLD\u2010only population (7.26 per 1000 person\u2010years (95% CI 2.97\u201311.56)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Coexistent CKD affects one in seven individuals with MASLD worldwide, conferring a more than two\u2010fold increased risk of all\u2010cause mortality compared with individuals with MASLD alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70747","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:22:27Z","timestamp":1782397347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Global Prevalence, Incidence, and Outcomes of Coexisting\n                    <scp>MASLD<\/scp>\n                    and Chronic Kidney Disease: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"46","author":[{"given":"Martin T. 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