{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:41:34Z","timestamp":1783100494276,"version":"3.54.6"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070588"],"award-info":[{"award-number":["82070588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370577"],"award-info":[{"award-number":["82370577"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1800801"],"award-info":[{"award-number":["2023YFA1800801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG CRC\/TR 412"],"award-info":[{"award-number":["DFG CRC\/TR 412"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatohepatitis (MASH) is an increasingly significant contributor to primary liver cancer in the Asia\u2010Pacific region, with substantial regional variation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>To quantify the burden and temporal trends of MASH\u2010related liver cancer across countries and subregions from 1990 to 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Global Burden of Disease (GBD) 2023 dataset, we analysed age\u2010standardized prevalence, deaths, and disability\u2010adjusted life years (DALYs) for MASH\u2010related liver cancer, assessing temporal trends, regional variation and associations with the Socio\u2010demographic Index (SDI). Decomposition analysis estimated the contributions of ageing, population growth and epidemiological changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2023, the high\u2010income Asia\u2010Pacific region had the highest age\u2010standardized prevalence of MASH\u2010related liver cancer (1.19 per 100\u2009000), followed by Oceania (0.98 per 100\u2009000) and Australasia (0.88 per 100\u2009000), with Central Asia the lowest (0.56 per 100\u2009000). Across the Asia\u2010Pacific region, prevalence, mortality and DALYs generally increased with SDI, though patterns varied by subregion. The high\u2010income Asia\u2010Pacific region showed a distinct \u2018increase\u2013peak\u2013decline\u2019 pattern in both mortality and DALYs, whereas low\u2010 and middle\u2010income regions (i.e., South Asia, South\u2010east Asia and Central Asia) showed steady increases in prevalence. Pacific island nations experienced disproportionately higher DALYs despite their smaller populations. Decomposition analyses showed that ageing and population growth accounted for the largest proportions of the observed changes in East Asia (44.8% and 41.4%, respectively) and South Asia (41.1% and 30.1%, respectively), whereas epidemiological change was the largest contributor in Australasia (58.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MASH\u2010related liver cancer is rising across the Asia\u2010Pacific region, with substantial regional variation, underscoring the need for region\u2010specific public health strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70752","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:00:47Z","timestamp":1781928047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Burden and Regional Disparities of\n                    <scp>MASH<\/scp>\n                    \u2010Related Liver Cancer in the Asia\u2010Pacific Region From 1990 to 2023"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0818","authenticated-orcid":false,"given":"Xiao\u2010Dong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hepatology, MAFLD Research Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Care Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"Institute of Aging, The Center for Geriatric Medicine The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-3900","authenticated-orcid":false,"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Verona  Verona Italy"},{"name":"Metabolic Diseases Research Unit IRCCS Sacro Cuore\u2014Don Calabria Hospital  Negrar di Valpolicella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-7753","authenticated-orcid":false,"given":"Christopher D.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southampton, University of Southampton, Southampton General Hospital  Southampton 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