{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:50:22Z","timestamp":1791377422909,"version":"4.3.2"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011099","name":"Deutsche Gesellschaft f\u00fcr Internationale Zusammenarbeit","doi-asserted-by":"publisher","award":["17.2170.3\u2010002.22"],"award-info":[{"award-number":["17.2170.3\u2010002.22"]}],"id":[{"id":"10.13039\/501100011099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Chronic hepatitis B virus (HBV) infection is endemic in Uzbekistan. Previous data showed a high prevalence of anti\u2010hepatitis D virus (HDV) antibodies in HBsAg\u2010positive individuals. Limited data are available on disease severity, treatment availability and hepatocellular carcinoma (HCC) prevalence in patients with chronic HDV infection in Uzbekistan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Scientific Research Institute of Virology (SRIoV) is the leading medical and scientific reference centre for viral hepatitis in Uzbekistan. In this retrospective study, epidemiological, clinical and laboratory data were collected and analysed from all HBsAg\u2010positive patients presenting to the SRIoV between June 2023 and May 2024. Data from HDV\u2010coinfected and HBV\u2010monoinfected patients were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data of 1393 individual patients were included. HDV coinfection was more prevalent than HBV\u2010monoinfection (73.9% [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091030\/1393]) vs. 26.1% [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009363\/1393]. HDV\u2010infected patients were significantly younger (41.9 vs. 45.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and showed higher rates of cirrhosis (78.4% vs. 43.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) with the majority of patients being classified as Child\u2013Pugh score B (57.8%). Only a minority of HDV\u2010coinfected patients has ever received anti\u2010HDV\u2010directed treatment (0.4%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094\/1030). Consecutively, HDV RNA was detectable in 78.9% (812\/1023) of patients. Quantitative HDV RNA was independently associated with ALT elevation\u2009&gt;\u2009upper limit of normal. The HCC detection rate was low in both patient groups due to insufficient screening measures (HDV:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097\/1030, HBV:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911\/363).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective cohort of 1393 individual patients, HDV coinfection exceeds HBV monoinfection in prevalence and disease severity. Most HDV\u2010infected patients present with advanced liver disease and currently lack access to HDV\u2010directed therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70799","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:36:15Z","timestamp":1784262975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High Rates of Advanced Chronic Liver Disease in Patients With Chronic Hepatitis D Virus Infection in Uzbekistan"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-8603","authenticated-orcid":false,"given":"Malika E.","family":"Khodjaeva","sequence":"first","affiliation":[{"name":"Scientific Research Institute of Virology  Tashkent Uzbekistan"},{"name":"Tashkent Medical State University  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziza S.","family":"Khikmatullaeva","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Virology  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nargiz S.","family":"Ibadullaeva","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Virology  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulnara K.","family":"Khudaykulova","sequence":"additional","affiliation":[{"name":"Tashkent Medical State University  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munisa M.","family":"Ilyasova","sequence":"additional","affiliation":[{"name":"Tashkent Medical State University  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila U.","family":"Eshbayeva","sequence":"additional","affiliation":[{"name":"Tashkent Medical State University  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dildorakhon N.","family":"Abdurakhmanova","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Virology  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-4506","authenticated-orcid":false,"given":"Helenie","family":"Kefalakes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"D\u2010SOLVE Consortium, an EU Horizon Europe\u2010Funded Project (No 101057917)  Hannover Germany"},{"name":"Excellence Cluster RESIST, Excellence Initiative Excellence Initiative Hannover Medical School  Hannover Germany"},{"name":"German Center for Infection Research (DZIF)  Hannover\/Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Gebel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkin I.","family":"Musabaev","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Virology  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-0480","authenticated-orcid":false,"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"D\u2010SOLVE Consortium, an EU Horizon Europe\u2010Funded Project (No 101057917)  Hannover Germany"},{"name":"Excellence Cluster RESIST, Excellence Initiative Excellence Initiative Hannover Medical School  Hannover Germany"},{"name":"German Center for Infection Research (DZIF)  Hannover\/Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Sandmann","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"},{"name":"D\u2010SOLVE Consortium, an EU Horizon Europe\u2010Funded Project (No 101057917)  Hannover Germany"},{"name":"Excellence Cluster RESIST, Excellence Initiative Excellence Initiative Hannover Medical School  Hannover Germany"},{"name":"German Center for Infection Research (DZIF)  Hannover\/Braunschweig 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