{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:01:17Z","timestamp":1793703677944,"version":"4.5.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Metabolic dysfunction\u2013associated steatotic liver disease (MASLD) is highly prevalent among patients with cardiovascular disease but remains underrecognized in routine cardiology practice. To address the limited prospective evidence on its progression and clinical impact, we established the CHAIN cohort, a prospective multicenter study enrolling approximately 15\u2009000 adults undergoing coronary evaluation across 40 tertiary hospitals in China. Baseline assessment includes comprehensive cardiometabolic profiling and vibration\u2010controlled transient elastography for evaluation of liver fibrosis and steatosis. Participants will undergo long\u2010term follow\u2010up with repeated liver assessments every 6\u201312\u2009months. Primary outcomes include liver\u2010related events and major adverse cardiovascular events, while secondary outcomes include longitudinal changes in liver fibrosis and steatosis and their associations with cardiometabolic risk factors and clinical outcomes. This cohort will provide longitudinal evidence to support risk stratification and integrated heart\u2013liver management in cardiovascular care.<\/jats:p>","DOI":"10.1111\/liv.70805","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:01:11Z","timestamp":1784178071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["CHAIN Cohort: Prospective Multicenter Study of MASLD With Serial Liver Stiffness Assessments in Cardiovascular Care"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0818","authenticated-orcid":false,"given":"Xiao\u2010Dong","family":"Zhou","sequence":"first","affiliation":[{"name":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2948-6962","authenticated-orcid":false,"given":"Ren Cheng\u2010Han","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the Heart Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-9024","authenticated-orcid":false,"given":"Jian\u2010Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3122-3904","authenticated-orcid":false,"given":"Xi\u2010Qiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5899-7910","authenticated-orcid":false,"given":"Qian","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of Jilin University  Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Hang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hepatology The First Hospital of Jilin University  Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Central Hospital of Shandong First Medical University  Jinan Shandong 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9060-5107","authenticated-orcid":false,"given":"Ming\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Hangzhou Normal University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1567-5569","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Affiliated Hospital of Hangzhou Normal University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Bing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Traditional Chinese Medicine Hospital, Xinjiang Medical University  Xinjiang 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