{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:18:07Z","timestamp":1787833087272,"version":"build-2784847793"},"reference-count":192,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The Paris International Liver Meeting (January 19\u201321, 2026) brought together leading hepatology experts to discuss transformative advances in chronic liver disease management. The meeting highlighted pivotal developments reflecting the field's evolution from disease characterisation toward precision, mechanism\u2010based therapeutics. Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction\u2010associated steatohepatitis (MASH), were highlighted, marking the transition to an era of approved disease\u2010modifying therapies. Resmetirom and semaglutide are now approved for MASH with F2\u2013F3 fibrosis, with a robust pipeline generating anti\u2010fibrotic signals through FGF21 analogs, pan\u2010peroxisome proliferator\u2010activated receptor (PPAR) agonists, and incretin\u2010based dual and triple agonists. Non\u2010invasive tests have evolved beyond their original diagnostic role to enable prognostic stratification, screening of at\u2010risk populations, treatment selection, and monitoring of therapeutic response. This evolution is not limited to MASLD, but extends to other chronic liver diseases, including primary biliary cholangitis (PBC) and portal hypertension, as highlighted by the recommendations of the Baveno Consensus Workshops. Hepatitis B and D are moving toward functional cure strategies, with simplified HBV treatment algorithms based on fibrosis and viral load, supported by biomarkers for risk stratification and safe treatment discontinuation. In parallel, HDV management is transitioning from a severe disease to one with emerging suppressive and potential curative l through bulevirtide and novel HBsAg\u2010targeting and RNA\u2010silencing therapies, respectively. Management of PBC has advanced with novel PPAR agonists that improve cholestatic biochemistry and pruritus, supported by individualised risk stratification. However, significant treatment gaps persist, with fewer than half of eligible PBC patients receiving second\u2010line therapy, and fatigue remains a major unmet clinical need. Furthermore, effective pharmacotherapies for primary sclerosing cholangitis (PSC) remain a major challenge, and no approved disease\u2010modifying treatments are currently available. Finally, for patients with hepatocellular carcinoma (HCC), immunotherapy combinations can achieve unprecedented long\u2010term survival in selected populations of patients. Collectively, these advances define a new era of hepatology centered on precision medicine, earlier intervention, and mechanism\u2010driven therapeutic strategies.<\/jats:p>","DOI":"10.1111\/liv.70806","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T04:00:41Z","timestamp":1787112041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatology: Emerging Paradigms in MASLD, Viral Hepatitis, Cholestatic Liver Disease, Portal Hypertension and Hepatocellular Carcinoma"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-577X","authenticated-orcid":false,"given":"Zobair M.","family":"Younossi","sequence":"first","affiliation":[{"name":"Global NASH\/MASH Council  Washington DC USA"},{"name":"Global Center for Liver Outcomes &amp; Policy Research Georgetown University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3518-4060","authenticated-orcid":false,"given":"George","family":"Papatheodoridis","sequence":"additional","affiliation":[{"name":"Global NASH\/MASH Council  Washington DC USA"},{"name":"1st Department of Gastroenterology Medical School of National and Kapodistrian University of Athens, General Hospital of Athens \u2018Laiko\u2019  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5069-2461","authenticated-orcid":false,"given":"Emmanuel","family":"Tsochatzis","sequence":"additional","affiliation":[{"name":"Global NASH\/MASH Council  Washington DC USA"},{"name":"University College of London UCL Institute for Liver and Digestive Health, Royal Free Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9620-9812","authenticated-orcid":false,"given":"Maria","family":"Buti","sequence":"additional","affiliation":[{"name":"Hepatology\u2010Internal Medicine, Vall D'hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9957-3615","authenticated-orcid":false,"given":"Lorenza","family":"Rimassa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University, Pieve Emanuele  Milan Italy"},{"name":"Hepatopancreatobiliary Oncology Unit Humanitas Cancer Center, IRCCS, Humanitas Research Hospital, Rozzano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Pinzani","sequence":"additional","affiliation":[{"name":"University College of London UCL Institute for Liver and Digestive Health, Royal Free Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-7902","authenticated-orcid":false,"given":"Ana","family":"Lleo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University, Pieve Emanuele  Milan Italy"},{"name":"Division of Internal Medicine and Hepatology, Department of Gastroenterology, IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-4619","authenticated-orcid":false,"given":"Debbie","family":"Shawcross","sequence":"additional","affiliation":[{"name":"The Roger Williams Institute of Liver Studies, Faculty of Life Sciences and Medicine King\u2019s College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-0226","authenticated-orcid":false,"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[{"name":"Global NASH\/MASH Council  Washington DC USA"},{"name":"Department of Hepatology &amp; Gastroenterology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow\u2010Klinikum and Campus Charit\u00e9 Mitte  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2215-9410","authenticated-orcid":false,"given":"Vincent Wai\u2010Sun","family":"Wong","sequence":"additional","affiliation":[{"name":"Global NASH\/MASH Council  Washington DC USA"},{"name":"Medical Data Analytics Center, Department of Medicine and Therapeutics The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-7497","authenticated-orcid":false,"given":"Shira","family":"Zelber\u2010Sagi","sequence":"additional","affiliation":[{"name":"Global NASH\/MASH Council  Washington DC USA"},{"name":"School of Public Health, Faculty of Social Welfare and Health Sciences University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-948X","authenticated-orcid":false,"given":"Andreas E.","family":"Kremer","sequence":"additional","affiliation":[{"name":"Global NASH\/MASH Council  Washington DC USA"},{"name":"Department of Gastroenterology and Hepatology, Swiss HPB Center University Hospital Z\u00fcrich, University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"J. 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