{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:18:05Z","timestamp":1787833085823,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Prognostic non\u2010invasive tests for liver\u2010related events in compensated cirrhosis are needed. Endotrophin, a fragment of type VI alpha 3 collagen involved in fibrosis and inflammation, has been associated with adverse outcomes in several chronic diseases. This study examined the association between baseline endotrophin levels, measured by nordicPRO\u2010C6 (PRO\u2010C6), and liver\u2010related events in advanced hepatitis C virus (HCV)\u2010related liver disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>nordicPRO\u2010C6 was assessed in baseline serum from 339 patients with advanced liver fibrosis from the Hepatitis C Antiviral Long\u2010Term Treatment Against Cirrhosis (HALT\u2010C) trial. The prognostic value of PRO\u2010C6 was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline serum levels of PRO\u2010C6 were significantly higher in patients with cirrhosis and PRO\u2010C6 was an independent prognostic marker for liver\u2010related events. Each doubling of PRO\u2010C6 was associated with increased hazard of liver\u2010related events in all patients (hazard ratio (HR)\u2009=\u20092.22, 95% confidence interval (CI) 1.57\u20133.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and in patients with cirrhosis (HR\u2009=\u20091.71, 95% CI 1.14\u20132.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Endotrophin assessed by PRO\u2010C6 is an independent prognostic marker for liver\u2010related events in patients with advanced liver fibrosis and ongoing inflammation due to HCV, particularly in those with cirrhosis, from the HALT\u2010C trial. PRO\u2010C6 may be useful for risk stratification in end\u2010stage liver disease. However, validation in non\u2013interferon\u2010treated cohorts and across chronic liver diseases of varying etiologies is required to confirm its prognostic value for liver\u2010related events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70824","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:28:51Z","timestamp":1786728531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endotrophin Measured by\n                    <scp>PRO<\/scp>\n                    \u2010\n                    <scp>C6<\/scp>\n                    as a Prognostic Biomarker for Liver\u2010Related Events in Patients With Advanced Chronic Liver Disease"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6030-5556","authenticated-orcid":false,"given":"Thomas","family":"Wiggers","sequence":"first","affiliation":[{"name":"The Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Nordic Bioscience A\/S  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3875-488X","authenticated-orcid":false,"given":"Emilie Toft","family":"Skovgaard","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Nordic Bioscience A\/S  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Karsdal","sequence":"additional","affiliation":[{"name":"Nordic Bioscience A\/S  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3805","authenticated-orcid":false,"given":"Jens Juul","family":"Holst","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Nordic Bioscience A\/S  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa","family":"de Zawadzki","sequence":"additional","affiliation":[{"name":"Nordic Bioscience A\/S  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4256-140X","authenticated-orcid":false,"given":"Diana Julie","family":"Leeming","sequence":"additional","affiliation":[{"name":"Nordic Bioscience A\/S  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4677-3127","authenticated-orcid":false,"given":"Keyur","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Health Network  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"S. 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