{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:46:47Z","timestamp":1791910007301,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2414202"],"award-info":[{"award-number":["2023YFC2414202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471960"],"award-info":[{"award-number":["82471960"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20343"],"award-info":[{"award-number":["U22A20343"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024ZDZX0017"],"award-info":[{"award-number":["2024ZDZX0017"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC1799"],"award-info":[{"award-number":["2024NSFSC1799"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Nonperipheral washout is a major imaging feature of hepatocellular carcinoma (HCC) with prognostic value, but whether its temporal differentiation can refine prognostic stratification remains understudied. This study aimed to investigate the prognostic implications of nonperipheral washout timing in HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre, retrospective cohort study included patients who underwent curative resection for single BCLC stage 0\/A HCC and preoperative extracellular contrast agent\u2013enhanced MRI at seven tertiary centres (March 2011 to April 2023). Three masked radiologists independently evaluated nonperipheral washout patterns, which were classified as early (present in the portal venous phase), late (present only in the delayed phase), or absent. Early recurrence\u2010free survival (eRFS; \u2264\u20092\u2009years) and 5\u2010year RFS were assessed using Kaplan\u2013Meier and Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 611 patients (median age, 55\u2009years; 520 men) were included. Early, late, and no washout were observed in 367 (60.1%), 95 (15.5%), and 149 (24.4%) patients, respectively. Inter\u2010 and intra\u2010reader agreements were substantial to excellent (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      range, 0.67\u20130.94). Early washout was associated with microvascular invasion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and Edmondson\u2013Steiner G3\/4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The eRFS rates were 67.3%, 82.1%, and 85.2% for the early, late, and no\u2010washout groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); the 5\u2010year RFS rates were 53.4%, 62.1%, and 71.8% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). In multivariable Cox analysis adjusting for factors, early washout independently predicted eRFS (HR, 1.86;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 5\u2010year RFS (HR, 1.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients undergoing curative resection for single BCLC 0\/A HCC, temporal differentiation of nonperipheral washout refines prognostic stratification, with early washout identifying patients at higher risk of recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70838","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:43:43Z","timestamp":1787723023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Temporal Differentiation of Nonperipheral Washout Refines Prognostic Stratification in\n                    <scp>HCC<\/scp>"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-3211","authenticated-orcid":false,"given":"Yingyi","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University  Chengdu 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