{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:52:08Z","timestamp":1790805128074,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Portal vein thrombosis (PVT) is a significant complication of cirrhosis. Nonselective beta\u2010blockers (NSBBs) are standard therapy for portal hypertension, but their effect on PVT risk remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess whether NSBB use after variceal band ligation increases PVT risk and to compare outcomes among propranolol, carvedilol and no NSBB therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using the TriNetX US Collaborative Network (&gt;\u2009110 million patients). Adults with cirrhosis and portal hypertension who underwent variceal band ligation (2010\u20132024) were included. Patients were stratified by NSBB exposure and matched 1:1 on 12 clinical variables. The primary outcome was incident PVT; secondary outcome was all\u2010cause mortality. Kaplan\u2013Meier analysis evaluated time\u2010to\u2010event outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094296 per group), NSBB use was associated with higher PVT incidence compared with no NSBBs (9.5% vs. 5.4%; RR 1.765, 95% CI 1.500\u20132.077). Propranolol was associated with increased PVT risk, whereas carvedilol showed similar PVT incidence to controls and significantly lower mortality compared with both propranolol and no NSBB use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Propranolol use was linked to increased PVT risk, while carvedilol did not elevate PVT risk and was associated with improved survival. Beta\u2010blocker selection may meaningfully influence outcomes in cirrhosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70843","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:17:22Z","timestamp":1787725042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Portal Vein Thrombosis Risk in Cirrhotic Patients With Portal Hypertension on Beta\u2010Blockers: A Multi\u2010Institutional Cohort Study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-8702","authenticated-orcid":false,"given":"Hazem","family":"Abosheaishaa","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  Queens New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5554-6252","authenticated-orcid":false,"given":"Khaled","family":"Elfert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7672-2896","authenticated-orcid":false,"given":"Mohammed","family":"Abusuliman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1854-4569","authenticated-orcid":false,"given":"Abdellatif","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Digestive Disease and Surgery Institute, Cleveland Clinic\u2010Florida  Weston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9138-8850","authenticated-orcid":false,"given":"Abdullah","family":"Olimy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Menoufia University, Menoufia Governorate  Shebin El\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3817-5370","authenticated-orcid":false,"given":"Ahmed Elsayed","family":"Alzamzamy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Maadi Armed Forces Medical Complex Military Medical Academy  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2482-0495","authenticated-orcid":false,"given":"Ahmed","family":"Omran","sequence":"additional","affiliation":[{"name":"Trinitas Regional Medical Center, RWJBH  Elizabeth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5530-447X","authenticated-orcid":false,"given":"Vincent","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai  Queens New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5401-9562","authenticated-orcid":false,"given":"Mahmoud","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jacobs School of Medicine and Biomedical Sciences University at Buffalo  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-6894","authenticated-orcid":false,"given":"Mohamed","family":"El\u2010Kassas","sequence":"additional","affiliation":[{"name":"Endemic Medicine Department, Faculty of Medicine Capital University (Formerly Helwan University)  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"StatPearls","author":"Samant H.","year":"2024"},{"issue":"4","key":"e_1_2_13_3_1","first-page":"3189","article-title":"The Risk Factors of Portal Vein Thrombosis in Patients With Liver Cirrhosis","volume":"17","author":"Cagin Y. 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