{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:18:05Z","timestamp":1787833085638,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hepatitis C virus (HCV) diagnosis in low\u2010 and middle\u2010income countries (LMICs) relies on costly and technically demanding centralized laboratory services. This review aims to synthesize evidence on Point\u2010of\u2010Care (POC) HCV testing in LMICs to inform scale\u2010up for HCV elimination. We searched Medline, Embase, PsycINFO, and the Cochrane Library for studies on decentralized POC HCV testing in LMICs between 2010 and 2022. Two reviewers independently conducted eligibility assessment and full text review. Testing uptake and linkage data were extracted using Excel, then descriptively synthesized to identify common patterns. Our systematic review identified 2018 reports of which 1603 underwent title and abstract screening. Among them, 58 met the eligibility criteria, but only 20 reports proceeded to data extraction. Of these, 16 examined feasibility and effectiveness, showing high testing uptake and linkage to care. In the 11 reports where services provided onsite testing and\/or treatment, uptake of testing and\/or treatment exceeded 90%. Four studies assessed HCV self\u2010testing among high\u2010risk populations and showed high acceptability (91%\u201399%). Studies evaluating oral\u2010based self\u2010testing among high\u2010risk populations reported higher recommendation rates (94%\u201399%) compared to that of blood\u2010based testing (86.1%). Our findings suggest that decentralized HCV testing and care models likely improve testing uptake and treatment success in LMICs, given the high rates of retention in care and cure.<\/jats:p>","DOI":"10.1111\/liv.70844","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T03:48:12Z","timestamp":1787111292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acceptability and Effectiveness of Point\u2010of\u2010Care\n                    <scp>HCV<\/scp>\n                    Testing in Low\u2010 and Middle\u2010Income Countries: A Systematic Review"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6387-9396","authenticated-orcid":false,"given":"Win Lei","family":"Yee","sequence":"first","affiliation":[{"name":"Department of Public Health and Primary Care Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6804-278X","authenticated-orcid":false,"given":"Thin Mar","family":"Win","sequence":"additional","affiliation":[{"name":"Burnet Institute Myanmar  Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2624-2510","authenticated-orcid":false,"given":"Bridget","family":"Draper","sequence":"additional","affiliation":[{"name":"Disease Elimination Program Burnet Institute  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Duc","family":"Pham","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Global Adolescent Health Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Department of Pediatrics University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-3266","authenticated-orcid":false,"given":"Margaret","family":"Hellard","sequence":"additional","affiliation":[{"name":"Disease Elimination Program Burnet Institute  Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases The Alfred Hospital  Melbourne Victoria Australia"},{"name":"Doherty Institute  Melbourne Victoria Australia"},{"name":"School of Population and Global Health University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5235-5629","authenticated-orcid":false,"given":"Stanley","family":"Luchters","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Ghent University  Ghent Belgium"},{"name":"Centre for Sexual Health and HIV AIDS Research (CeSHHAR)  Harare Zimbabwe"},{"name":"Liverpool School of Tropical Medicine (LSTM)  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Global Hepatitis Report, 2017 (2017)","author":"World Health Organization","year":"2017"},{"key":"e_1_2_13_3_1","volume-title":"Global Health Sector Strategy on Viral Hepatitis 2016\u20132021: Towards Ending Viral Hepatitis","author":"World Health Organization","year":"2016"},{"key":"e_1_2_13_4_1","unstructured":"World Health Organization \u201cHepatitis C: Key Facts: World Health Organization \u201d(2021) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hepatitis\u2010c."},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.07.013"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.54394\/CJQU6666"},{"key":"e_1_2_13_7_1","volume-title":"Global Health Sector Strategies on, Respectively, HIV, Viral Hepatitis and Sexually Transmitted Infections for the Period 2022\u20132030","author":"World Health Organization","year":"2022"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31012-1"},{"issue":"1","key":"e_1_2_13_9_1","first-page":"3","article-title":"HIV and Hepatitis Testing: Global Progress, Challenges, and Future Directions","volume":"18","author":"Easterbrook P.","year":"2016","journal-title":"AIDS Reviews"},{"key":"e_1_2_13_10_1","volume-title":"Progress Report on Access to Hepatitis C Treatment; 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