{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:04:57Z","timestamp":1792652697773,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Body composition is increasingly recognised as a prognostic determinant in cirrhosis, particularly in liver transplant (LT) candidates. We aimed to assess adipose and muscle compartments on computed tomography (CT) before and after LT and to evaluate their associations with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We recruited prospectively 121 patients with cirrhosis listed for LT. CT scans at the third lumbar vertebral level were analysed to quantify cross\u2010sectional area (cm\n                      <jats:sup>2<\/jats:sup>\n                      ) and density (Hounsfield units, HU) of skeletal muscle, subcutaneous adipose tissue (SAT), and visceral adipose tissue. A subset underwent a CT\u2010scan 6\u2009months post\u2010LT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most patients were male (76%), and the median MELD score was 14 (IQR 10\u201320). High SAT density (&gt;\u2009\u221283 HU in women; &gt;\u2009\u221274 HU in men) was associated with higher pre\u2010transplant mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and with reduced overall survival during follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) compared to lower SAT density. The combined phenotype of low muscle density and high SAT density identified the subgroup with the poorest survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). From baseline to 6\u2009months post\u2010LT, SAT density decreased significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0134), whereas muscle parameters did not change significantly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This prospective observational cohort study demonstrates that SAT density is a prognostic CT\u2010derived marker in patients with cirrhosis awaiting LT with significant post\u2010transplant dynamics. The impact of altered adipose tissue therefore warrants attention in this situation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70862","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:46:47Z","timestamp":1788529607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Subcutaneous Fat Density Is an Independent Predictor of Adverse Outcomes and Shows Early Improvement After Liver Transplantation"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-7650","authenticated-orcid":false,"given":"G\u00e9raldine","family":"Dahlqvist","sequence":"first","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie Cliniques universitaires Saint\u2010Luc  Brussels Belgium"},{"name":"Laboratoire de Gastro\u2010Ent\u00e9rologie et d'H\u00e9patologie (GAEN), Institut de Recherche Exp\u00e9rimentale et Clinique (IREC) UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3544-9055","authenticated-orcid":false,"given":"Salom\u00e9","family":"Declerck","sequence":"additional","affiliation":[{"name":"Laboratoire de Gastro\u2010Ent\u00e9rologie et d'H\u00e9patologie (GAEN), Institut de Recherche Exp\u00e9rimentale et Clinique (IREC) UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1568-7111","authenticated-orcid":false,"given":"Maxence","family":"Lepour","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie Cliniques universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Delorme","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie Cliniques universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3808-2109","authenticated-orcid":false,"given":"Alix","family":"Collard","sequence":"additional","affiliation":[{"name":"Statistical Support Cliniques universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Trefois","sequence":"additional","affiliation":[{"name":"Radiology Department Cliniques universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-9314","authenticated-orcid":false,"given":"Nicolas","family":"Lanthier","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie Cliniques universitaires Saint\u2010Luc  Brussels Belgium"},{"name":"Laboratoire de Gastro\u2010Ent\u00e9rologie et d'H\u00e9patologie (GAEN), Institut de Recherche Exp\u00e9rimentale et Clinique (IREC) UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(19)30349\u20108"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11121907"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.51821\/86.1.12052"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15571"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/LVT.0000000000000010"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071216"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.51821\/85.4.10899"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i40.5807"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.11.005"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2473627"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010021\u201007099\u20108"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29578"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12688"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.70204"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.70088"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100495"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1272728"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111141"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab285"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2022.09.016"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.70733"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15927"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201079718\u20109"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2036205"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2024.102428"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/rco2.70012"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.004"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006491"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29219"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31406"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2025.102743"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24750"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15577"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.111203"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00744.2004"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2026.103370"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123300"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.07.003"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22695"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20200022"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2021.101272"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i31.10682"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.70862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.70862","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.70862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:40:27Z","timestamp":1791556827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.70862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/liv.70862"],"URL":"https:\/\/doi.org\/10.1111\/liv.70862","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"assertion":[{"value":"2026-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70862"}}