{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:52:59Z","timestamp":1791557579639,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["115\u20102314\u2010B\u2010182A\u2010185\u2010MY3"],"award-info":[{"award-number":["115\u20102314\u2010B\u2010182A\u2010185\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infection is a major cause of mortality in patients with cirrhosis. However, chronic organ dysfunction may confound the interpretation of organ dysfunction scores, and the prognostic value of the updated Sequential Organ Failure Assessment\u20102 (SOFA\u20102) score in cirrhotic patients with suspected infection remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective multi\u2010institutional cohort study across four hospitals in Taiwan from January 2010 to December 2021. Adult patients admitted from the emergency department (ED) with suspected infection were included and stratified by cirrhosis status. The primary outcome was 28\u2010day mortality. SOFA\u20102 score distributions, domain\u2010specific patterns and mortality associations were compared between patients with and without cirrhosis. Cox proportional hazards models with site\u2010clustered robust standard errors were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 150\u2009511 patients with suspected infection, 4288 (2.9%) had cirrhosis. Patients with cirrhosis had higher SOFA\u20102 scores than those without cirrhosis (median, 4 [interquartile range (IQR), 2\u20136] vs. 2 [IQR, 0\u20134];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and higher non\u2010hepatic SOFA\u20102 scores (median, 3 [IQR, 1\u20135] vs. 1 [IQR, 0\u20133];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The 28\u2010day mortality rate was 14.9% in patients with cirrhosis and 8.9% in those without cirrhosis. After adjustment for age, sex, non\u2010hepatic Charlson Comorbidity Index and non\u2010hepatic SOFA\u20102 score, cirrhosis remained associated with higher 28\u2010day mortality (adjusted hazard ratio, 1.31; 95% confidence interval, 1.17\u20131.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among ED patients with suspected infection, cirrhosis was associated with an increased risk of SOFA\u20102\u2010defined organ dysfunction and increased mortality. SOFA\u20102 may support early risk stratification but should be interpreted in the context of cirrhosis\u2010related baseline physiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70867","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:02:48Z","timestamp":1788940968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SOFA<\/scp>\n                    \u20102 Score and Mortality in Suspected Infection Stratified by Cirrhosis Status: A Multi\u2010Institutional Observational Cohort Study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-8175","authenticated-orcid":false,"given":"Chieh\u2010Ching","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"Department of Emergency Medicine New Taipei Municipal 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