{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:12:28Z","timestamp":1792653148051,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aim<\/jats:title>\n                    <jats:p>Sustained\u2010virological\u2010response (SVR) after direct\u2010acting\u2010antiviral (DAA) therapy improves outcomes in patients with HCV\u2010related compensated\u2010advanced\u2010chronic\u2010liver\u2010disease (cACLD). However, it remains unclear whether absolute post\u2010SVR LSM or LSM reduction better predicts prognosis after SVR. This study evaluated the prognostic performance of absolute\u2010values\u2010LSM versus dynamic\u2010change for predicting liver\u2010related\u2010events after SVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed patients with HCV\u2010related cACLD treated with DAA between December 2014 and March 2022. Baseline and post\u2010SVR non\u2010invasive tests (LSM, FIB\u20104 and APRI) were assessed. Predictive performance for liver\u2010related events was evaluated using time\u2010dependent receiver operating characteristic analysis. Associations between Baveno\u2010VII criteria for clinically significant LSM improvement and clinical outcomes were assessed using Fine\u2013Grey competing\u2010risk models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median of 60\u2009months (95%; CI 52\u201369), 11\/135 patients (8%) developed liver\u2010related events. Patients who developed events had higher baseline LSM than those who remained event\u2010free (24 vs. 18\u2009kPa,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049), and higher follow\u2010up LSM values (20 vs. 12\u2009kPa,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043). Follow\u2010up LSM showed good discriminative ability for liver\u2010related events within the first 3\u2009years after SVR (tAUC at 2\u2009years: 0.86 [95% CI 0.75\u20130.97]; tAUC at 3\u2009years: 0.82 [0.71\u20130.93]). Follow\u2010up LSM was significantly superior to \u0394LSM and percentage \u0394LSM at both 2 and 3\u2009years (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.028). In competing\u2010risk analysis, only follow\u2010up LSM\u2009&gt;\u200920\u2009kPa was significantly associated with liver\u2010related events (subdistribution hazard ratio 5.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), whereas Baveno\u2010VII criteria for LSM regression were not (SHR 0.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.097).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Absolute post\u2010treatment\u2010LSM provides stronger prognostic information than dynamic changes from baseline. These findings support repeated post\u2010SVR LSM assessment for risk stratification suggesting the relevance of residual liver disease in predicting liver\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70869","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:14:30Z","timestamp":1789535670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Value of Liver Stiffness in Advanced Chronic Liver Disease After Hepatitis C Virus Eradication"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3568-1531","authenticated-orcid":false,"given":"Federica","family":"Cerini","sequence":"first","affiliation":[{"name":"Hepatology Unit San Giuseppe Hospital, University of Milan  Milan Italy"},{"name":"Department of Clinical Sciences and Community Health University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-8528","authenticated-orcid":false,"given":"Mariagrazia","family":"Rumi","sequence":"additional","affiliation":[{"name":"Hepatology Unit San Giuseppe Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6346-8362","authenticated-orcid":false,"given":"Jonas","family":"Schropp","sequence":"additional","affiliation":[{"name":"Department for Visceral Medicine and Surgery, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Department of Biomedical Research University of Bern  Bern Switzerland"},{"name":"Bavarian Center for Digital Health and Social Care Kempten University of Applied Sciences  Kempten Germany"},{"name":"Graduate School for Health Sciences University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Cosenza","sequence":"additional","affiliation":[{"name":"Hepatology Unit San Giuseppe Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Selvaggio","sequence":"additional","affiliation":[{"name":"Hepatology Unit San Giuseppe Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Masellis","sequence":"additional","affiliation":[{"name":"Hepatology Unit San Giuseppe Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4562-9016","authenticated-orcid":false,"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[{"name":"Department for Visceral Medicine and Surgery, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Department of Biomedical Research University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00472-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.08.006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.016"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.05.050"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20506"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01087.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28824"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31462"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.08.025"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.022"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25993"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12623"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.06.001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"e_1_2_11_17_2","doi-asserted-by":"crossref","unstructured":"Erratum in: J Hepatol2019 Apr;70(4):817 https:\/\/doi.org\/10.1016\/j.jhep.2019.01.020.","DOI":"10.1016\/j.jhep.2019.01.020"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(96)00075-X"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5958"},{"key":"e_1_2_11_20_1","volume-title":"Multiple Imputation for Nonresponse in Surveys","author":"Rubin D. 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