{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:53:04Z","timestamp":1791557584591,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Liver cirrhosis is associated with an increased risk of bacterial infections, but there is a lack of reliable population\u2010based data to quantify this risk. We examined the incidence and predictors of community\u2010acquired serious systemic infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a population\u2010based study that included all patients in the Central Denmark Region diagnosed with alcohol\u2010related cirrhosis (ALD cirrhosis) in 2013\u20132022. We computed the cumulative incidence of community\u2010acquired serious systemic infections, encompassing sepsis and bacteraemia. We used Fine &amp; Gray regression to investigate predictors of infection within the first year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 2511 patients with ALD cirrhosis (69.3% males, median age 61\u2009years, median MELD\u2010NA score 13). Their cumulative risk of a first\u2010time community\u2010acquired serious systemic infection was 3.8% (95% CI: 3.1\u20134.6) after 1\u2009year and 5.9% (95% CI: 5.0\u20136.9) after 3\u2009years. The most frequent causative pathogens were Enterobacterales (38%), Staphylococci (25%) and Streptococci (22%). Increasing MELD\u2010Na score at cirrhosis diagnosis was associated with an increased risk of serious systemic infection within the first year after diagnosis (subdistribution hazard ratio\u2009=\u20091.05, 95% CI: 1.02\u20131.08, per 1 point increase). The 30\u2010day all\u2010cause mortality was 30% (95% CI: 23\u201337) following hospitalization with a serious systemic infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This population\u2010based study determined the risk and mortality of serious systemic infections in ALD cirrhosis. Our findings will be important for future studies of interventions to prevent infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70881","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:49:54Z","timestamp":1789462194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and Mortality of Community\u2010Acquired Sepsis or Bacteraemia in Patients With Alcohol\u2010Related Cirrhosis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3076-513X","authenticated-orcid":false,"given":"Clara Juul","family":"Stenderup","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2287-7017","authenticated-orcid":false,"given":"Margarita","family":"Dudina","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-7999","authenticated-orcid":false,"given":"Kirstine Kobber\u00f8e","family":"S\u00f8gaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5137-7268","authenticated-orcid":false,"given":"Morten Daniel","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-1430","authenticated-orcid":false,"given":"Peter","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus 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