{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:50:40Z","timestamp":1791269440749,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Autoimmune hepatitis is an immune\u2010mediated liver disease characterized by chronic inflammation and progressive fibrosis. Tissue\u2010resident memory T cells mediate organ\u2010specific immunity, but their role in autoimmune hepatitis remains poorly understood. We characterized tissue\u2010residency\u2010associated T\u2010cell populations and their cytokine profiles, assessed associations with disease severity and determined whether these signatures were reflected in peripheral blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Paired blood and liver samples were obtained from 19 patients with autoimmune hepatitis. Comparator cohorts included 20 patients with metabolic dysfunction\u2010associated steatotic liver disease and 20 surgical patients providing non\u2010inflamed adjacent non\u2010tumorous liver tissue. Multiparameter flow cytometry assessed tissue\u2010residency markers, T\u2010cell differentiation and cytokine production after polyclonal stimulation. Immune phenotypes were correlated with histological and clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Autoimmune hepatitis was associated with compartment\u2010specific remodelling of T\u2010cell differentiation states and intrahepatic enrichment of CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells expressing CD69, CD103 and CXCR6 relative to paired blood and comparator liver tissues. Intrahepatic CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells exhibited an interferon\u2010\u03b3\u2010dominant cytokine profile, whereas CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells showed broader interferon\u2010\u03b3\u2010, interleukin\u201017A\u2010 and interleukin\u20104\u2010associated responses. Despite the enrichment of tissue\u2010residency\u2010associated CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells, cytokine\u2010producing CD8\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell populations with and without a tissue\u2010resident memory phenotype contributed comparably to the hepatic T\u2010cell compartment. Tissue\u2010residency\u2010associated phenotypes correlated positively with Ishak fibrosis stage, whereas the frequency of interferon\u2010\u03b3\u2010positive intrahepatic CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells correlated inversely with fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Autoimmune hepatitis was characterized by intrahepatic accumulation of phenotypically distinct and functionally active CD8\n                      <jats:sup>+<\/jats:sup>\n                      tissue\u2010resident memory T cells associated with fibrosis. This immune profile was not reflected in paired blood, indicating compartmentalized hepatic immune remodelling.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70897","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:51:50Z","timestamp":1791265910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrahepatic Tissue\u2010Resident\n                    <scp>CD8<\/scp>\n                    <sup>+<\/sup>\n                    T\u2010Cell Programmes Associate With Fibrosis and Local Immune Remodelling in Autoimmune Hepatitis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-9934","authenticated-orcid":false,"given":"Victoria","family":"Stary","sequence":"first","affiliation":[{"name":"Division of Visceral Surgery, Department of General Surgery, Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6418-7767","authenticated-orcid":false,"given":"Sarah","family":"Losek","sequence":"additional","affiliation":[{"name":"Division of Visceral Surgery, Department of General Surgery, Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-7934","authenticated-orcid":false,"given":"Magdalena","family":"Mairinger","sequence":"additional","affiliation":[{"name":"Division of Visceral Surgery, Department of General Surgery, Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0257-4844","authenticated-orcid":false,"given":"Gerhard","family":"Prager","sequence":"additional","affiliation":[{"name":"Division of Visceral Surgery, Department of General Surgery, Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-9735","authenticated-orcid":false,"given":"Jonas","family":"Santol","sequence":"additional","affiliation":[{"name":"Department of Surgery, HPB Center Vienna Health Network, Clinic Favoriten and Sigmund Freud Private University  Vienna Austria"},{"name":"Department of Surgery, Division of Hepatobiliary and Pancreas Surgery Mayo Clinic  Rochester Minnesota USA"},{"name":"Institute of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-5337","authenticated-orcid":false,"given":"Patrick P.","family":"Starlinger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreas Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-3583","authenticated-orcid":false,"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Christian Doppler Laboratory for Portal Hypertension and Liver Fibrosis Medical University of Vienna  Vienna Austria"},{"name":"CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0737-4091","authenticated-orcid":false,"given":"Albert F.","family":"St\u00e4ttermayer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna 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