{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:55:58Z","timestamp":1790776558800,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Within the global population living with human immunodeficiency virus (HIV), achieving hepatitis C virus (HCV) micro\u2010elimination is a crucial public health strategy. We assessed the HCV care continuum among people with HIV (PWH) in Yunnan Province, China, a region with a historically high burden of both infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Linked data from provincial HIV and HCV surveillance systems (January 2022\u2013June 2025) were analysed. An eight\u2010stage care continuum was constructed, ranging from anti\u2010HCV testing to sustained virologic response. Annual trends in the HCV care cascade were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 143\u2009959 PWH, 90.3% underwent anti\u2010HCV testing. Of the 20\u2009627 individuals who tested anti\u2010HCV positive, 67.3% were referred to the national surveillance system; among those reported, 84.7% tested positive for HCV RNA. Among individuals who were HCV RNA positive, 85.0% initiated direct\u2010acting antiviral treatment; the rate was 87.7% among those who were alive and retained in care. Those who completed post\u2010treatment assessment demonstrated a sustained virologic response rate of 99.1%. Between January 2022 and June 2025, the HCV RNA positivity rate among reported cases increased from 44.6% to 84.7%, with treatment initiation increasing from 77.5% to 85.0%. Subgroup analyses identified lower testing and treatment uptake among individuals lost to follow\u2010up, those who died, and certain demographics such as older adults and farmers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Yunnan has made significant strides toward HCV micro\u2010elimination among PWH, demonstrating the feasibility of integrating HCV services into existing HIV care platforms. The findings may be useful to other resource\u2010limited settings seeking to achieve elimination targets established by the World Health Organization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70899","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:02:22Z","timestamp":1790773342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating HCV Testing and Treatment Into HIV Care: A Cohort Study of the HCV Care Cascade in Southwest China"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7887-0108","authenticated-orcid":false,"given":"Minyang","family":"Xiao","sequence":"first","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"},{"name":"Yunnan Key Laboratory of Cross\u2010Border Infectious Disease Control and Prevention and Novel Drug Development (Under Construction)  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuntao","family":"Liu","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"},{"name":"Yunnan Key Laboratory of Cross\u2010Border Infectious Disease Control and Prevention and Novel Drug Development (Under Construction)  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Ma","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"},{"name":"Yunnan Provincial Key Laboratory of Public Health and Biosafety  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"},{"name":"Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liru","family":"Fu","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6248-5705","authenticated-orcid":false,"given":"Zhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Shi","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"},{"name":"Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manhong","family":"Jia","sequence":"additional","affiliation":[{"name":"Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine)  Kunming China"},{"name":"Yunnan Provincial Key Laboratory of Public Health and Biosafety  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2799-0051","authenticated-orcid":false,"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for AIDS\/STD Control and Prevention Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization \u201cGlobal Hepatitis Report 2024: Action for Access in Low\u2010 and Middle\u2010Income Countries \u201d(2024) 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L.","year":"2022","journal-title":"Chinese Journal of AIDS & STD"},{"key":"e_1_2_12_19_1","unstructured":"People's Government of Yunnan Province \u201cNotice of the General Office of the People's Government of Yunnan Province on the Issuance of the \u201cYunnan Province Plan for Containment and Prevention of AIDS (2025\u20132030)\u201d \u201d(2025)."},{"issue":"2","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","DOI":"10.1002\/jia2.25051","article-title":"Linkage and Retention in HCV Care for HIV\u2010Infected Populations: Early Data From the DAA Era","volume":"21","author":"Sacks\u2010Davis R.","year":"2018","journal-title":"Journal of the International AIDS Society"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287909"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13280"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16060885"},{"issue":"2","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.18683\/germs.2025.1464","article-title":"The Status of Hepatitis C Microelimination Among People Living With HIV in Central and Eastern Europe in 2022 \u2010 Data From Euroguidelines in Central and Eastern Europe Network Group","volume":"15","author":"Skrzat\u2010Klapaczy\u0144ska A.","year":"2025","journal-title":"Germs"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13658"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0256164"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3138\/canlivj-2024-0042"},{"issue":"10","key":"e_1_2_12_28_1","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofz426","article-title":"Hepatitis C Elimination in People With HIV Is Contingent on Closing Gaps in the HIV Continuum","volume":"6","author":"Falade\u2010Nwulia O.","year":"2019","journal-title":"Open Forum Infectious Diseases"},{"issue":"5","key":"e_1_2_12_29_1","first-page":"334","article-title":"Why 395 HIV\/AIDS Patients Failed to Receive HAART","volume":"19","author":"Pei\u2010long L.","year":"2013","journal-title":"Chinese Journal of AIDS & STD"},{"key":"e_1_2_12_30_1","volume-title":"Epidemiological Evaluation and Influencing Factors of HIV Diagnosis and Treatment in Shandong Province [Dissertation]","author":"Zhang N.","year":"2018"},{"issue":"7","key":"e_1_2_12_31_1","first-page":"761","article-title":"Progress and Prospects in the Prevention and Treatment of Hepatitis C in China","volume":"28","author":"Li J.","year":"2022","journal-title":"Chinese Journal of AIDS & STD"},{"key":"e_1_2_12_32_1","unstructured":"Disease Control and Prevention Administration of Yunnan Province \u201cHCV Curable Covered by Insurance With Government Aid Available for Needy Patients \u201d(2024) https:\/\/ynsjkj.yn.gov.cn\/html\/2024\/jikongkepu_1121\/235.html."},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.70200"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.70899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.70899","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.70899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:02:27Z","timestamp":1790773347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.70899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/liv.70899"],"URL":"https:\/\/doi.org\/10.1111\/liv.70899","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70899"}}