{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:50:53Z","timestamp":1791269453247,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["IN\u2010IT\u2010980\u20106816"],"award-info":[{"award-number":["IN\u2010IT\u2010980\u20106816"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012781","name":"Merck Sharp and Dohme K.K.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001690","name":"Atsumi International Scholarship Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Hepatitis D virus (HDV) infection has historically been more prevalent among people with HIV (PWH) due to shared transmission routes. Whether HIV status still identifies a subgroup at higher risk of HDV in contemporary settings remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed two cross\u2010sectional analyses assessing anti\u2010HDV prevalence among HBsAg\u2010positive PWH enrolled in the ICONA cohort in 2009\u20132012 and 2019\u20132023, compared with HIV\u2010negative individuals from the MASTER and PITER cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Anti\u2010HDV prevalence among PWH declined from 19.1% to 12.5%, converging with that observed in HIV\u2010negative individuals (12.7%). Injection drug use markedly decreased over time among PWH and remained the strongest determinant of HDV infection. In multivariable analyses, HDV seropositivity was associated with age, injection drug use, and birth outside Italy, but not with HIV infection in the contemporary period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate that HIV infection is no longer independently associated with HDV infection in this setting and support universal HDV screening strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70913","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:00:34Z","timestamp":1791266434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Hepatitis D Virus Prevalence Among HBsAg\u2010Positive Individuals With and Without HIV in Italy: A Converging Epidemiology"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3278-7138","authenticated-orcid":false,"given":"Massimo","family":"Puoti","sequence":"first","affiliation":[{"name":"School of Medicine University Milano Bicocca  Milan Italy"},{"name":"Infectious Diseases Department ASST Grande Ospedale Metropolitano Niguarda  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-451X","authenticated-orcid":false,"given":"Alessandro","family":"Tavelli","sequence":"additional","affiliation":[{"name":"Icona Foundation  Milan Italy"},{"name":"National PhD Programme in One Health Approaches to Infectious Diseases and Life Science Research, Department of Public Health, Experimental and Forensic Medicine University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5643-0139","authenticated-orcid":false,"given":"Giuseppina","family":"Brancaccio","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Health and Health Professions Infectious Diseases Link Campus University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1077-1488","authenticated-orcid":false,"given":"Maria Giovanna","family":"Quaranta","sequence":"additional","affiliation":[{"name":"National Center for Global Health, Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1392-9874","authenticated-orcid":false,"given":"Maria Elena","family":"Tosti","sequence":"additional","affiliation":[{"name":"National Center for Global Health, Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1573-6224","authenticated-orcid":false,"given":"Giovanni Battista","family":"Gaeta","sequence":"additional","affiliation":[{"name":"Infectious Diseases, University L. Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2656-224X","authenticated-orcid":false,"given":"Loreta A.","family":"Kondili","sequence":"additional","affiliation":[{"name":"National Center for Global Health, Istituto Superiore di Sanit\u00e0  Rome Italy"},{"name":"UniCamillus\u2010Saint Camillus International University of Health Sciences  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-1789","authenticated-orcid":false,"given":"Antonella","family":"d\u2019Arminio Monforte","sequence":"additional","affiliation":[{"name":"Icona Foundation  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PITER, MASTER and ICONA Study Groups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"24","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1001\/jama.2023.23242","article-title":"Hepatitis D: A Review","volume":"330","author":"Negro F.","year":"2023","journal-title":"Journal of the American Medical Association"},{"issue":"7","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1111\/liv.70189","article-title":"Hepatitis D Virus Infection: Pathophysiology, Epidemiology and Treatment. Report From the Third Delta Cure Meeting 2024","volume":"45","author":"Degasperi E.","year":"2025","journal-title":"Liver International"},{"issue":"4","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/liv.15519","article-title":"Hepatitis Delta Infection Among Persons Living With HIV in Europe","volume":"43","author":"B\u00e9guelin C.","year":"2023","journal-title":"Liver International"},{"issue":"2","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/liv.15804","article-title":"Determinants of Worse Liver\u2010Related Outcome According to HDV Infection Among HBsAg Positive Persons Living With HIV: Data From the ICONA Cohort","volume":"44","author":"d'Arminio Monforte A.","year":"2024","journal-title":"Liver International"},{"issue":"2","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/jvh.13899","article-title":"Epidemiology of Hepatitis D Virus Infection in Europe: Is It Vanishing?","volume":"31","author":"Demirel A.","year":"2024","journal-title":"Journal of Viral Hepatitis"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/00002030-200003310-00005","article-title":"Insight Into the Reasons for Discontinuation of the First Highly Active Antiretroviral Therapy (HAART) Regimen in a Cohort of Antiretroviral na\u00efve Patients","volume":"14","author":"d'Arminio Monforte A.","year":"2000","journal-title":"AIDS"},{"issue":"3","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.dld.2018.09.008","article-title":"The Present Profile of Chronic Hepatitis B Virus Infection Highlights Future Challenges: An Analysis of the Multicenter Italian MASTER\u2010B Cohort","volume":"51","author":"Brancaccio G.","year":"2019","journal-title":"Digestive and Liver Disease"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijid.2024.107115","article-title":"A Holistic Evaluation of Patients With Chronic Hepatitis D Virus (HDV) Infection Enrolled in the Italian PITER\u2010B and Delta Cohort","volume":"146","author":"Kondili L. A.","year":"2024","journal-title":"International Journal of Infectious Diseases"},{"issue":"3","key":"e_1_2_10_10_1","first-page":"267","article-title":"Demographic and Socio\u2010Economic Determinants of Poor HIV\u2010Risk Perception at First HIV Diagnosis: Analysis of the HIV Surveillance Data, Italy 2010\u20102016","volume":"56","author":"Dorrucci M.","year":"2020","journal-title":"Annali Dell'istituto Superiore di Sanita"},{"issue":"10","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1007\/s10461-023-04051-x","article-title":"The Impact of Needle and Syringe Exchange Programs on HIV\u2010Related Risk Behaviors in Low\u2010 and Middle\u2010Income Countries: A Systematic Review and Meta\u2010Analysis Examining Individual\u2010 Versus Community\u2010Level Effects","volume":"27","author":"Yeh P. T.","year":"2023","journal-title":"AIDS and Behavior"},{"issue":"9","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","DOI":"10.1111\/liv.70242","article-title":"The Medical Impact of Hepatitis D Virus Infection in Natives and Immigrants: The Italian Paradigm","volume":"45","author":"Caviglia G. P.","year":"2025","journal-title":"Liver International"},{"issue":"4","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/QAI.0000000000002589","article-title":"Efficacy and Safety of Elvitegravir\/Cobicistat\/Emtricitabine\/Tenofovir Alafenamide as Maintenance Treatment in HIV\/HBV\u2010Coinfected Patients","volume":"86","author":"Huang Y. S.","year":"2021","journal-title":"Journal of Acquired Immune Deficiency Syndromes"},{"issue":"10","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"e640","DOI":"10.1016\/S2352-3018(23)00151-0","article-title":"Bictegravir, Emtricitabine, and Tenofovir Alafenamide Versus Dolutegravir, Emtricitabine, and Tenofovir Disoproxil Fumarate for Initial Treatment of HIV\u20101 and Hepatitis B Coinfection (ALLIANCE): A Double\u2010Blind, Multicentre, Randomised Controlled, Phase 3 Non\u2010Inferiority Trial","volume":"10","author":"Avihingsanon A.","year":"2023","journal-title":"Lancet HIV"},{"issue":"2","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jhep.2016.10.007","article-title":"Hepatitis Delta\u2010Associated Mortality in HIV\/HBV\u2010Coinfected Patients","volume":"66","author":"B\u00e9guelin C.","year":"2017","journal-title":"Journal of Hepatology"},{"issue":"5","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/COH.0000000000000297","article-title":"Reducing Rates of Preventable HIV\/AIDS\u2010Associated Mortality Among People Living With HIV Who Inject Drugs","volume":"11","author":"Parashar S.","year":"2016","journal-title":"Current Opinion in HIV and AIDS"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.70913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.70913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.70913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:00:37Z","timestamp":1791266437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.70913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/liv.70913"],"URL":"https:\/\/doi.org\/10.1111\/liv.70913","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"assertion":[{"value":"2026-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70913"}}