{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:50:18Z","timestamp":1791881418484,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["GAP606; File No: 5\/4\/8\u201010\/OBS\/MKP\/2021\u2010NCD\u2010II; 30\/03\/2021"],"award-info":[{"award-number":["GAP606; File No: 5\/4\/8\u201010\/OBS\/MKP\/2021\u2010NCD\u2010II; 30\/03\/2021"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Extracellular vesicles (EVs) play a crucial role in intercellular communication, particularly in metabolic regulation and liver disease. This study aimed to investigate the differential effects of EVs derived from pre\u2010adipocytes (PA) and mature adipocytes (MA) on hepatic stellate cell (HSC) activation in\u00a0vitro and their role in promoting liver fibrosis in high\u2010fat diet (HFD)\u2010fed mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EVs were isolated from PA and MA following transdifferentiation, which was confirmed by assessing adipogenic markers (PPAR\u2010\u03b3, perilipin, adiponectin, leptin, and Glut4). EVs were characterized by size and CD9 expression. LX\u20102 cells were treated with PA\u2010 or MA\u2010derived EVs to assess fibrotic and inflammatory gene expression. In\u00a0vivo, C57BL\/6 mice on HFD were administered PA\u2010EVs or MA\u2010EVs to evaluate liver pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MA\u2010EVs exhibited a distinct transcriptomic profile and significantly upregulated fibrotic (\u03b1\u2010SMA, COL1A1) and inflammatory markers in LX\u20102 cells, indicating HSC activation. Conversely, PA\u2010EVs had minimal effects. In HFD\u2010fed mice, MA\u2010EVs injection led to pronounced liver damage, including steatosis, inflammation, and fibrosis, compared with mice receiving PA\u2010EVs, which showed no major pathological changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MA\u2010EVs aggravate liver fibrosis and inflammation both in\u00a0vitro and In\u00a0vivo, while PA\u2010EVs appear to have relatively limited effects. These findings highlight the functional heterogeneity of adipocyte\u2010derived EVs and suggest MA\u2010EVs as potential contributors to the pathogenesis of metabolic dysfunction\u2010associated steatotic liver disease (MASLD). Targeting specific EV subpopulations may present novel therapeutic strategy for MASLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70914","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:18:22Z","timestamp":1791879502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mature Adipocyte\u2010Derived Extracellular Vesicles Activate Hepatic Stellate Cells and Promote Liver Fibrosis via Inflammation"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-6828","authenticated-orcid":false,"given":"Venkat","family":"Prashanth","sequence":"first","affiliation":[{"name":"Department of Biochemistry CSIR\u2010Central Food Technological Research Institute  Mysore India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-6574","authenticated-orcid":false,"given":"Sachin","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CSIR\u2010Central Food Technological Research Institute  Mysore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anbarasu","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CSIR\u2010Central Food Technological Research Institute  Mysore India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8173-9506","authenticated-orcid":false,"given":"Madan Kumar","family":"Perumal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CSIR\u2010Central Food Technological Research Institute  Mysore India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.1002\/jcp.29567","article-title":"EID1 Suppresses Lipid Accumulation by Inhibiting the Expression of GPDH in 3T3\u2010L1 Preadipocytes","volume":"235","author":"Sato T.","year":"2020","journal-title":"Journal of Cellular Physiology"},{"key":"e_1_2_14_3_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11883-016-0575-4","article-title":"Obesity and Cardiovascular Disease: A Risk Factor or a Risk Marker?","volume":"18","author":"Mandviwala T.","year":"2016","journal-title":"Current Atherosclerosis Reports"},{"key":"e_1_2_14_4_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13098-020-00570-y","article-title":"NAFLD as a Continuum: From Obesity to Metabolic Syndrome and Diabetes","volume":"12","author":"Godoy\u2010Matos A. 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