{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:44:55Z","timestamp":1791787495819,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alcohol\u2010related hepatitis (AH) is an acute form of liver disease with a high short\u2010term mortality. A variety of treatments have been explored in randomised studies. Recent consensus on study outcomes has identified 90\u2010day survival as the primary outcome metric.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This systematic review and network meta\u2010analysis is to update understanding of the comparative efficacy of treatments for AH, based on 90\u2010day survival, to inform future Phase III studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, Ovid\u2010Medline and Embase were searched for randomised studies of treatments of AH. The risk of bias in included papers was measured using the Cochrane risk of bias 2 tool. Data were synthesised with network meta\u2010analysis to estimate risk ratio (RR) of survival at 90\u2009days after randomisation. Heterogeneity was assessed with the magnitude of the between\u2010study variance (tau\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty five studies including 5045 participants were identified that examined 24 treatments for AH. Twenty\u2010three studies were considered to be at low risk of bias. In network meta\u2010analysis considering placebo as the reference treatment, only granulocyte colony stimulating factor (GCSF) showed a statistically significant benefit on 90\u2010day mortality (RR 0.49, 95% CI 0.28\u20130.84;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). In subgroup analysis of studies at low risk of bias, no treatments showed a significant effect on mortality at 90\u2009days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individual studies are small and heterogeneity is marked; however, some agents show promise to improve survival at 90\u2009days in people with AH. This information should inform adequately powered studies to explore potential treatments for AH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70922","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:49:48Z","timestamp":1791784188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Network Meta\u2010Analysis: Treatments for Acute Alcohol\u2010Associated Hepatitis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6153-4933","authenticated-orcid":false,"given":"Charles","family":"Gallaher","sequence":"first","affiliation":[{"name":"Department of Gastroenterology University Hospital Lewisham  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-4830","authenticated-orcid":false,"given":"Guruprasad P.","family":"Aithal","sequence":"additional","affiliation":[{"name":"Department of Hepatology Nottingham University Hospitals NHS Trust  Nottingham UK"},{"name":"School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-0193","authenticated-orcid":false,"given":"Ashwin","family":"Dhanda","sequence":"additional","affiliation":[{"name":"Department of Hepatology University Hospitals Plymouth NHS Trust  Plymouth UK"},{"name":"Faculty of Health University of Plymouth  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7293-2574","authenticated-orcid":false,"given":"Ewan","family":"Forrest","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology NHS Greater Glasgow and Clyde  Glasgow UK"},{"name":"School of Medicine University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-2816","authenticated-orcid":false,"given":"James","family":"O'Beirne","sequence":"additional","affiliation":[{"name":"University of the Sunshine Coast  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0453-3168","authenticated-orcid":false,"given":"Ken","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Department of Medicine University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-192X","authenticated-orcid":false,"given":"Mark","family":"Thursz","sequence":"additional","affiliation":[{"name":"NIHR Imperial Biomedical Research Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4888-8670","authenticated-orcid":false,"given":"Richard","family":"Parker","sequence":"additional","affiliation":[{"name":"Leeds Liver Unit St James's University Hospital  Leeds UK"},{"name":"Leeds Institute for Medical Research University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/apt.70383","article-title":"Meta\u2010Analysis: Mortality Trends and Risk Factors in Severe Alcohol\u2010Associated Hepatitis","volume":"62","author":"Siddique M. 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