{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:43:11Z","timestamp":1792478591528,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Both liver fat content (LFC) and intrapancreatic fat deposition (IPFD) are frequently increased in Type 2 diabetes mellitus (T2DM). We meta\u2010analysed dual\u2010organ MRI studies comparing LFC between individuals with T2DM and non\u2010diabetic controls and explored whether study\u2010level differences in LFC varied according to IPFD burden. Seventeen studies (2142 participants) were included. Individuals with T2DM had significantly higher LFC than non\u2010diabetic controls (standardised mean difference [SMD] 0.89, 95% CI 0.60\u20131.18). In exploratory subgroup analyses, liver fat excess was larger in studies with mean IPFD \u2265\u200910% than in those with IPFD &lt;\u200910% (SMD 1.20 vs. 0.62;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04), though this finding was not consistently retained in leave\u2010one\u2010out analyses. Alternative IPFD cutoffs yielded directionally similar but non\u2010significant subgroup differences. Study\u2010level differences in IPFD were associated with differences in LFC (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.383,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006) in univariable meta\u2010regression, but not after BMI adjustment. These findings suggest that higher IPFD is associated with greater liver fat excess in T2DM at the study level. Individual\u2010level analyses are now warranted to clarify this relationship.\n                  <\/jats:p>","DOI":"10.1111\/liv.70934","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:30:41Z","timestamp":1792477841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excess Liver Fat in Type 2 Diabetes Stratified by Intrapancreatic Fat Deposition: A Meta\u2010Analysis of Dual\u2010Organ\n                    <scp>MRI<\/scp>\n                    Studies"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5930-268X","authenticated-orcid":false,"given":"Hyun Hee","family":"Sul","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Jersey City Medical Center\/Rutgers Health  Jersey City New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1458-1398","authenticated-orcid":false,"given":"Saeed","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-165X","authenticated-orcid":false,"given":"Pojsakorn","family":"Danpanichkul","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3695-9701","authenticated-orcid":false,"given":"Matheus","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Federal University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-9062","authenticated-orcid":false,"given":"Maxim S.","family":"Petrov","sequence":"additional","affiliation":[{"name":"School of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUTJNL\u20102023\u2010330110"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21\u20101262"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2026.113149"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2026.0444"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000297"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010015\u20100404\u20101"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24154"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2023.1213441"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEPR.2023.100998"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.N71"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMASURG.2021.0522"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679\u2010026\u201000718\u20103"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201014\u2010135"},{"key":"e_1_2_11_15_1","unstructured":"G. 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