{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:40:35Z","timestamp":1792586435921,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2025ZD01906000"],"award-info":[{"award-number":["2025ZD01906000"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Steatotic liver disease (SLD) is an increasingly important cause of hepatocellular carcinoma (HCC), yet validated risk stratification tools remain limited. We aim to evaluate the aMAP score, initially developed for HCC risk prediction mainly in viral hepatitis across international cohorts, in the SLD population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>156\u2009406 SLD participants were included from the UK Biobank (UKB) and 3166 SLD patients with virally suppressed chronic hepatitis B from a Chinese cohort. The predictive and stratification performance of the aMAP score was assessed and compared with the PAGE\u2010B, mPAGE\u2010B, CAMD and MASLD\u2010HCC scores. A refined stratification of the aMAP\u2010defined high\u2010risk population identified a subgroup exceeding the recommended surveillance threshold.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow\u2010up was 13.64\u2009years in UKB and 9.97\u2009years in the Chinese cohort, with 287 and 58 patients developing HCC, respectively. The aMAP score showed favourable discrimination (C\u2010indices: 0.80 [95% CI, 0.78\u20130.83] in UKB; 0.79 [95% CI, 0.73\u20130.85] in the Chinese cohort). The 15\u2010year cumulative HCC incidence by aMAP in UKB was 0.06% (95% CI, 0.04%\u20130.08%), 0.26% (95% CI, 0.21%\u20130.31%) and 1.43% (95% CI, 1.14%\u20131.72%) for low\u2010, intermediate\u2010 and high\u2010risk groups (high vs. low risk, sHR: 28.51; 95% CI, 19.58\u201341.52; Gray's test\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Consistent results were found across etiological subgroups and in the other cohort (Gray's test\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The refined cutoff (aMAP\u2009&gt;\u200964) identified a very\u2010high\u2010risk subgroup in UKB with 15\u2010year cumulative incidences of 3.08% (training; 95% CI, 1.29%\u20134.87%) and 5.35% (validation; 95% CI, 3.04%\u20137.67%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The aMAP score is an effective tool for HCC risk stratification among SLD patients. The refined aMAP threshold accurately identifies very\u2010high\u2010risk patients qualifying for guideline\u2010recommended surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.70936","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:50:40Z","timestamp":1792583440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <scp>aMAP<\/scp>\n                    Score Effectively Stratifies Hepatocellular Carcinoma Risk in the Steatotic Liver Disease Population"],"prefix":"10.1111","volume":"46","author":[{"given":"Wenxin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Key Laboratory of Infectious Diseases Research in South China Ministry of Education  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Viral Hepatitis  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Key Laboratory of Infectious Diseases Research in South China Ministry of Education  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Viral Hepatitis  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Key Laboratory of Infectious Diseases Research in South China Ministry of Education  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Prevention and Control of Major Liver Diseases  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Viral Hepatitis  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ma","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Hepatology First Hospital, University of Jilin  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-8803","authenticated-orcid":false,"given":"Qing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-3872","authenticated-orcid":false,"given":"Huiying","family":"Rao","sequence":"additional","affiliation":[{"name":"Peking University Hepatology Institute Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6046-5756","authenticated-orcid":false,"given":"Song","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University  Beijing China"},{"name":"Department of Infectious Disease China\u2010Japan Friendship Hospital  Beijing 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