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We performed a systematic review of the literature to identify the frequency, lower urinary tract symptoms (<jats:styled-content style=\"fixed-case\">LUTS<\/jats:styled-content>), urodynamic findings, putative underlying pathology, and management of bladder dysfunction in patients with depression\/anxiety. From a recent survey of a depression cohort (at a psychiatry clinic), the frequency of bladder dysfunction in depression is lower (up to 25.9%) than that in <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arkinson's disease (up to 75%) and stroke (up to 55%), whereas it is significantly higher than that in age\u2010matched controls (around 10%). In both the depression cohort and the psychogenic bladder dysfunction cohort (at a urology clinic), the most common <jats:styled-content style=\"fixed-case\">LUTS<\/jats:styled-content> was overactive bladder (<jats:styled-content style=\"fixed-case\">OAB<\/jats:styled-content>), followed by difficult urination and infrequent voiding. Compared with severe <jats:styled-content style=\"fixed-case\">LUTS<\/jats:styled-content>, urodynamic findings were dissociated; i.e. urodynamic findings were normal except for increased bladder sensation without detrusor overactivity for <jats:styled-content style=\"fixed-case\">OAB<\/jats:styled-content> (50% of all patients), followed by underactive detrusor without post\u2010void residual for difficult urination. The effectiveness of serotonergic or anti\u2010cholinergic medication for ameliorating <jats:styled-content style=\"fixed-case\">OAB<\/jats:styled-content> in the patients awaits further study. In conclusion, although the frequency of <jats:styled-content style=\"fixed-case\">LUTS<\/jats:styled-content> among the depression cohort is not elevated, depression\/anxiety is obviously a risk factor for <jats:styled-content style=\"fixed-case\">OAB<\/jats:styled-content>. This finding presumably reflects that the bladder is under emotional control. Amelioration of bladder dysfunction is an important target in treating patients with depression\/anxiety.<\/jats:p>","DOI":"10.1111\/luts.12018","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T02:08:43Z","timestamp":1364782123000},"page":"109-120","source":"Crossref","is-referenced-by-count":54,"title":["Depression, Anxiety and the Bladder"],"prefix":"10.1111","volume":"5","author":[{"given":"Ryuji","family":"SAKAKIBARA","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine, Sakura Medical Center Toho University  Sakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"ITO","sequence":"additional","affiliation":[{"name":"Division of Neurology Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"YAMAMOTO","sequence":"additional","affiliation":[{"name":"Division of Neurology Chiba University  Chiba 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