{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:18:25Z","timestamp":1791227905325,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Objectives<\/jats:title>This study aimed to determine whether or not a urodynamic study (UDS<\/jats:styled-content>) is beneficial for management of pediatric nocturnal enuresis (NE<\/jats:styled-content>), especially in pharmacoresistant monosymptomatic nocturnal enuresis (PRMNE<\/jats:styled-content>) or severe non\u2010monosymptomatic nocturnal enuresis (NMNE<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Children with PRMNE<\/jats:styled-content> or severe NMNE<\/jats:styled-content> who underwent a UDS<\/jats:styled-content> for the process of NE<\/jats:styled-content> treatment were retrospectively reviewed. The UDS<\/jats:styled-content> findings of patients and treatment outcomes of subsequent tailored therapies according to the UDS<\/jats:styled-content> findings were analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 80 children (50 boys and 30 girls, mean age 8.4\u2009\u00b1\u20092.2\u2009years), 19 of which were diagnosed with PRMNE<\/jats:styled-content> and 61 of which were diagnosed with NMNE<\/jats:styled-content>, were included in the final analysis. Of the 19 PRMNE<\/jats:styled-content> children, 12 (63.2%) demonstrated abnormal UDS<\/jats:styled-content> findings. Ten demonstrated detrusor overactivity (DO<\/jats:styled-content>) with or without decreased cystometric bladder capacity (CBC<\/jats:styled-content>); the treatment outcomes markedly improved in all of the children after anticholinergics were added to the initial desmopressin therapy. Biofeedback was found to be helpful for two children with detrusor\u2010sphincter dyssynergia. All of the total 61 children with NMNE<\/jats:styled-content> demonstrated abnormal urodynamic findings of DO<\/jats:styled-content> with or without decreased CBC<\/jats:styled-content>, and 42 (68.9%) achieved more than partial response (>\u200950% decrease in the number of wet nights) when given a combination therapy of anticholinergics and desmopressin.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The urodynamic findings were helpful for guiding children with PRMNE<\/jats:styled-content> in the proper choice of further treatment strategies. A routine UDS<\/jats:styled-content> should not be recommended prior to a first\u2010line combination treatment in children with NMNE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12024","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T11:52:25Z","timestamp":1371642745000},"page":"88-93","source":"Crossref","is-referenced-by-count":9,"title":["Role of Urodynamic Study in Nocturnal Enuresis: Urodynamic Findings and Treatment Outcome Correlation in Children with Pharmacotherapy\u2010resistant Monosymptomatic Nocturnal Enuresis or Severe Non\u2010monosymptomatic Nocturnal Enuresis"],"prefix":"10.1111","volume":"6","author":[{"given":"Dong Soo","family":"RYU","sequence":"first","affiliation":[{"name":"Department of Urology Samsung Changwon Hospital, Sungkyunkwan University School of Medicine Changwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Won","family":"LEE","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Won","family":"KWAK","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Changwon Hospital, Sungkyunkwan University School of Medicine Changwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan Hyun","family":"PARK","sequence":"additional","affiliation":[{"name":"Department of Urology Seoul Samsung Urology Clinic\/Gynecology Health Care Center Ulsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minki","family":"BAEK","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul 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