{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:10:59Z","timestamp":1745467859347},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess whether urinary arginine vasopressin (<jats:styled-content style=\"fixed-case\">AVP<\/jats:styled-content>) concentrations adjusted for urinary creatinine (Cr) can predict responsiveness to low\u2010dose desmopressin for nocturia with nocturnal polyuria (<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> patients aged 64\u201384\u2009years with \u2265\u20092 nocturnal voids received 2.5\u2009\u00b5g of intranasal desmopressin for 4\u2009weeks and were evaluated for its effectiveness. Prior to treatment, urinary <jats:styled-content style=\"fixed-case\">AVP<\/jats:styled-content>\/Cr concentrations at first morning void and serum sodium and plasma natriuretic peptide (<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>) concentrations were measured, and all patients underwent 5% hypertonic saline infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six responders to 2.5\u2009\u00b5g desmopressin had average decreases in nocturnal frequency from 3.2 to 1.8 voids nightly and in nocturnal diuresis by 40%, without clinically significant adverse events. Non\u2010responders remained unaffected even with dose escalation to 5.0\u2009\u00b5g desmopressin. For responders, urinary <jats:styled-content style=\"fixed-case\">AVP<\/jats:styled-content>\/Cr concentrations were less than 14\u2009pg\/mg\u2009\u00b7\u2009Cr, which is lower than in non\u2010responders. Within a physiological range of plasma osmolality, plasma <jats:styled-content style=\"fixed-case\">AVP<\/jats:styled-content> release in response to 5% hypertonic saline infusion was less in responders than in non\u2010responders. Blood pressure measurements and <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> concentrations were unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Urinary <jats:styled-content style=\"fixed-case\">AVP\/Cr<\/jats:styled-content> at first morning void may have potential clinical value as a predictor for responsiveness to low\u2010dose desmopressin in nocturia with <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12028","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T04:33:26Z","timestamp":1376282006000},"page":"107-112","source":"Crossref","is-referenced-by-count":3,"title":["Preliminary Experience with Low\u2010dose Desmopressin Treatment and Urinary Arginine Vasopressin Concentration as a Response Predictor for Patients with Nocturia with Nocturnal 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