{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:52:07Z","timestamp":1791870727640,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T00:00:00Z","timestamp":1378339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Ketamine abuse may cause variable lower urinary tract symptoms and severe cystitis. In this study, we evaluated the relevance of urodynamic parameters according to the dose and duration of ketamine use and investigate the value of urodynamic studies in determining the severity of ketamine\u2010associated cystitis (<jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The urodynamic study results of 30 patients with <jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2009 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2012 were analyzed retrospectively. All patients had been diagnosed based on their history and clinical features before urodynamic investigations. Cystoscopy was performed to confirm the diagnosis and measure the maximum anesthetic bladder bladder capacity (<jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content>) (under spinal anesthesia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean (\u00b1 standard deviation) age of patients with <jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content> was 22.0\u2009\u00b1\u20093.3\u2009years. The mean duration of ketamine abuse was 39.0\u2009\u00b1\u200920.8\u2009months. Maximum cystometric capacity was 115\u2009\u00b1\u200966.6\u2009mL. Seventy\u2010five percent of patients had a high maximal urethral closure pressure (<jats:styled-content style=\"fixed-case\">MUCP<\/jats:styled-content>) (&gt;\u200990\u2009cmH<jats:sub>2<\/jats:sub>O). There was no significant difference of urodynamic parameters between the high\u2010dose (\u2265\u20095\u2009gm\/day) and low\u2010dose groups (&lt;\u20095\u2009gm\/day) or the long\u2010duration (\u2265\u20093\u2009years) and short\u2010duration (&lt;\u20093\u2009years) groups. However, the <jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content> was significantly lower in high\u2010dose and long\u2010duration groups compared to the low\u2010dose and short\u2010duration groups (191.3\u2009\u00b1\u200968.5 vs. 299.0\u2009\u00b1\u200999\u2009mL; <jats:italic>P<\/jats:italic>\u2009=\u20090.01; 219.0\u2009\u00b1\u200959.7 vs. 325.5\u2009\u00b1\u2009104.5\u2009mL; <jats:italic>P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The urodynamic test results help diagnose <jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content>, but may not be useful in determining the severity of the disease. The <jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content> measured under anesthesia may be a better predictor of the disease progression in <jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12029","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T04:12:43Z","timestamp":1378440763000},"page":"98-102","source":"Crossref","is-referenced-by-count":10,"title":["Is Urodynamic Study a Good Witness to the Progression of Ketamine\u2010Associated Cystitis?"],"prefix":"10.1111","volume":"6","author":[{"given":"Po\u2010Wei","family":"HUANG","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery Tri\u2010Service General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Tang","family":"WU","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tri\u2010Service General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Wei","family":"TSAO","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tri\u2010Service General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou\u2010Hung","family":"TANG","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tri\u2010Service General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai\u2010Lung","family":"CHA","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tri\u2010Service General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Huan","family":"SUN","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tri\u2010Service General Hospital Taipei 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