{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:42:19Z","timestamp":1696311739184},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy and safety of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>otulinum <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>oxin <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (BoNTA) intradetrusor injections in patients with neurogenic detrusor overactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients provided clinical history and voiding diary, submitted to clinical examination, urine culture; serum creatinine; imaging, including plain abdominal <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010rays, abdomino\u2010pelvic ultrasonography and voiding cystourethrogram; and urodynamic tests (<jats:styled-content style=\"fixed-case\">CMG<\/jats:styled-content>) . They were managed by intradetrusor injections of <jats:styled-content style=\"fixed-case\">BoNTA<\/jats:styled-content>. For the typical patient, 300 units of <jats:styled-content style=\"fixed-case\">BoNTA<\/jats:styled-content> were injected through 30 injections of 10\u2009u\/mL intradetrusally into equally spaced sites of the bladder wall, excluding the trigone, under cystoscopic guidance. Patients were commenced clean intermittent catheterizations (<jats:styled-content style=\"fixed-case\">CICs<\/jats:styled-content>) every 4\u20136\u2009h post\u2010injection. Follow up included voiding diaries, abdomino\u2010pelvic ultrasonography, serum creatinine and <jats:styled-content style=\"fixed-case\">CMG<\/jats:styled-content>, were completed for all patients at 6 and 12\u2009weeks. This study used <jats:styled-content style=\"fixed-case\">IBM SPSS V<\/jats:styled-content>ersion 20.0 for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five patients (28 males and 17 females) with a mean age of 19.6\u2009years were subjected to <jats:styled-content style=\"fixed-case\">BoNTA<\/jats:styled-content> intradetrusor injections. A good clinical response (dry patient either completely or more than 50% of the period between <jats:styled-content style=\"fixed-case\">CICs<\/jats:styled-content>) was observed in 68.9 and 66.7% of the patients after 6 and 12\u2009weeks of follow up, respectively. In the group that responded well, the mean bladder volume increased post\u2010injection by 48.2% and the mean maximum intravesical pressure decreased to 35.3\u2009cm <jats:styled-content style=\"fixed-case\">H<jats:sub>2<\/jats:sub>O<\/jats:styled-content>, a 33.4% improvement. No patients had side\u2010effects related to <jats:styled-content style=\"fixed-case\">BoNTA<\/jats:styled-content> or to the procedure, and no patients experienced a deterioration of their renal functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intradetrusor <jats:styled-content style=\"fixed-case\">BoNTA<\/jats:styled-content> injections provide a good clinical response. The urodynamic parameters significantly improved in patients with neurogenic detrusor overactivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12034","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T08:06:08Z","timestamp":1382688368000},"page":"162-166","source":"Crossref","is-referenced-by-count":0,"title":["Botulinum Toxin <scp>A<\/scp> Intradetrusor Injection for Treating Neurogenic Detrusor Overactivity, A Single Centre Experience"],"prefix":"10.1111","volume":"6","author":[{"given":"Hisham A.","family":"MOSLI","sequence":"first","affiliation":[{"name":"Department of Urology King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohannad A.","family":"AWAD","sequence":"additional","affiliation":[{"name":"Department of Urology King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamdouh M.","family":"REZK","sequence":"additional","affiliation":[{"name":"Department of Urology King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman E.","family":"ALSABBAN","sequence":"additional","affiliation":[{"name":"Department of Urology King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmalik M. 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