{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:37:55Z","timestamp":1790534275714,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T00:00:00Z","timestamp":1387756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Radiation treatment for pelvic malignancies is typically associated with radiation injury to urinary bladder that can ultimately lead to radiation cystitis (<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>). The late sequelae of radiation therapy may take many years to develop and include bothersome storage symptoms such as hematuria, which may be life\u2010threatening in severe cases of hemorrhagic cystitis. Although no definitive treatment is currently available, various interventions are used for radiation and hemorrhagic cystitis including blood transfusion, bladder irrigation, intravesical instillation of substances such as alum, silver nitrate, prostaglandins or formalin, and fulguration of intravesical bleeding sites and surgery options such as supravesical urinary diversions and cystectomy. Effects of non\u2010surgical treatments for radiation and hemorrhagic cystitis are of modest success and studies are lacking to control the effects caused by <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>. When such measures have proven ineffective, use of bladder botulinum toxin injection has been reported. New therapy, such as intravesical immunosuppression with local tacrolimus formulation is being developed for the treatment of radiation hemorrhagic cystitis.<\/jats:p>","DOI":"10.1111\/luts.12045","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T04:22:02Z","timestamp":1387858922000},"page":"1-10","source":"Crossref","is-referenced-by-count":17,"title":["Advances in Therapeutic Development for Radiation Cystitis"],"prefix":"10.1111","volume":"6","author":[{"given":"Bharathi Raja","family":"RAJAGANAPATHY","sequence":"first","affiliation":[{"name":"Department of Urology Centre for Urology Research Excellence, Oakland University William Beaumont School of Medicine Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal","family":"JAYABALAN","sequence":"additional","affiliation":[{"name":"Department of Urology Centre for Urology Research Excellence, Oakland University William Beaumont School of Medicine Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"TYAGI","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"KAUFMAN","sequence":"additional","affiliation":[{"name":"Lipella Pharmaceuticals Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"CHANCELLOR","sequence":"additional","affiliation":[{"name":"Department of Urology Centre for Urology Research Excellence, Oakland University William Beaumont School of Medicine Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00059-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/76700674"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.23"},{"key":"e_1_2_8_5_1","unstructured":"American Cancer Society Atlanta: Cancer Facts & Figures.2012. 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