{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T04:17:14Z","timestamp":1746159434906,"version":"3.40.4"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,2]],"date-time":"2014-03-02T00:00:00Z","timestamp":1393718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate pathways involving beta\u20103 adrenergic receptors (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>s) in detrusor overactivity induced by cold stress, we determined if the beta\u20103<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>agonist<jats:styled-content style=\"fixed-case\">CL316243<\/jats:styled-content>could modulate the cold stress\u2010induced detrusor overactivity in normal rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two\u2009days prior to cystometric investigations, the bladders of 10\u2010week\u2010old female<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2013<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats were cannulated. Cystometric measurements of the unanesthetized, unrestricted rats were taken to estimate baseline values at room temperature (RT, 27\u2009\u00b1\u20092\u2009\u00b0C) for 20\u2009min. They were then intravenously administered vehicle, 0.1, or 1.0\u2009mg\/kg<jats:styled-content style=\"fixed-case\">CL316243<\/jats:styled-content>(<jats:italic>n\u2009=<\/jats:italic>\u20096 in each group). Five\u2009minutes after the treatments, they were gently and quickly transferred to the low temperature (LT, 4\u2009\u00b1\u20092\u2009\u00b0C) room for 40\u2009min where the cystometric measurements were again made. Afterward, the rats were returned to<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>for final cystometric measurements. The cystometric effects of<jats:styled-content style=\"fixed-case\">CL316243<\/jats:styled-content>were also measured at<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>(<jats:italic>n\u2009=<\/jats:italic>\u20096 in each group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>, both low and high dose of<jats:styled-content style=\"fixed-case\">CL316243<\/jats:styled-content>decreased basal and micturition pressure while the high dose (1.0\u2009mg\/kg) significantly increased voiding interval and bladder capacity. During<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>exposure, the high dose of<jats:styled-content style=\"fixed-case\">CL316243<\/jats:styled-content>partially reduced cold stress\u2010induced detrusor overactivity characterized by increased basal pressure and urinary frequency. The high drug dose also significantly inhibited the decreases of both voiding interval and bladder capacity compared to the vehicle\u2010 and low dose (0.1\u2009mg\/kg)\u2010treated rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high dose of the beta\u20103 agonist<jats:styled-content style=\"fixed-case\">CL316243<\/jats:styled-content>could modulate cold stress\u2010induced detrusor overactivity. Therefore, one of the mechanisms in cold stress\u2010induced detrusor overactivity includes a pathway involving beta\u20103<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12050","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T09:51:14Z","timestamp":1393840274000},"page":"50-55","source":"Crossref","is-referenced-by-count":3,"title":["Pathways Involving Beta\u20103 Adrenergic Receptors Modulate Cold Stress\u2010Induced Detrusor Overactivity in Conscious Rats"],"prefix":"10.1111","volume":"7","author":[{"given":"Tetsuya","family":"IMAMURA","sequence":"first","affiliation":[{"name":"Department of Lower Urinary Tract Medicine Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"ISHIZUKA","sequence":"additional","affiliation":[{"name":"Department of Lower Urinary Tract Medicine Shinshu University School of Medicine Matsumoto Japan"},{"name":"Department of Urology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruyuki","family":"OGAWA","sequence":"additional","affiliation":[{"name":"Department of Urology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"YAMAGISHI","sequence":"additional","affiliation":[{"name":"Department of Urology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"YOKOYAMA","sequence":"additional","affiliation":[{"name":"Department of Urology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"MINAGAWA","sequence":"additional","affiliation":[{"name":"Department of Urology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"NAKAZAWA","sequence":"additional","affiliation":[{"name":"Department of Urology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"NISHIZAWA","sequence":"additional","affiliation":[{"name":"Department of Lower Urinary Tract Medicine Shinshu University School of Medicine Matsumoto Japan"},{"name":"Department of Urology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590701485921"},{"key":"e_1_2_6_3_1","article-title":"Relationship between toe temperature and lower urinary tract symptoms","volume":"4","author":"Inoue H","year":"2012","journal-title":"Low Urin Tract Symptoms"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20497"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20630"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-200101000-00071"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.12.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-3565(24)39317-6","article-title":"Role of the beta(3)\u2010adrenoceptor in urine storage in the rat: comparison between the selective beta(3)\u2010adrenoceptor agonist, CL316, 243, and various smooth muscle relaxants","volume":"293","author":"Takeda H","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-3565(24)38094-2","article-title":"Evidence for beta3\u2010adrenoceptor subtypes in relaxation of the human urinary bladder detrusor: analysis by molecular biological and pharmacological methods","volume":"288","author":"Takeda M","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.02.104"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000074622.50255.a8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22335"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64634-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.02.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.180885"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03893.x"},{"key":"e_1_2_6_17_1","article-title":"Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals","volume":"214","author":"Cruz CD","year":"2008","journal-title":"Exp Neurol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20253"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12050","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T23:42:29Z","timestamp":1746142949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,2]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/luts.12050"],"URL":"https:\/\/doi.org\/10.1111\/luts.12050","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"type":"print","value":"1757-5664"},{"type":"electronic","value":"1757-5672"}],"subject":[],"published":{"date-parts":[[2014,3,2]]}}}