{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T04:10:11Z","timestamp":1746159011878,"version":"3.40.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>As a proof\u2010of\u2010mechanism (<jats:styled-content style=\"fixed-case\">POM<\/jats:styled-content>) study of drugs developed to treat stress urinary incontinence (<jats:styled-content style=\"fixed-case\">SUI<\/jats:styled-content>) has not been conducted, this urodynamic study in healthy women was performed to determine an appropriate method to confirm<jats:styled-content style=\"fixed-case\">POM<\/jats:styled-content>, and to evaluate the effect of duloxetine, a serotonin and noradrenaline reuptake inhibitor, on urethral resting pressure and on sphincter contractility in response to coughing and magnetic stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The urethral pressure profiles at rest, during coughing and during sacral root magnetic stimulation (<jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content>), and the motor threshold (<jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>) for urethral sphincter contraction in response to transcranial magnetic stimulation (<jats:styled-content style=\"fixed-case\">TMS<\/jats:styled-content>) were measured before and 6\u2009h after the administration of 40\u2009mg duloxetine in 10 healthy female subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Oral administration of duloxetine significantly increased the mean and maximal urethral closure pressures at rest over the proximal and middle third of the urethra. During coughing, duloxetine marginally significantly increased the mean distal urethral pressure and significantly reduced the mean delay in the distal urethral pressure peak relative to the vesical peak. Although duloxetine did not change amplitudes of pressure spikes in response to<jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content>, this drug significantly lowered the<jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>in response to<jats:styled-content style=\"fixed-case\">TMS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proposed method for measuring the urethral resistance in healthy women can be used in<jats:styled-content style=\"fixed-case\">POM<\/jats:styled-content>studies of new drugs developed to treat<jats:styled-content style=\"fixed-case\">SUI<\/jats:styled-content>.<\/jats:p><jats:p><jats:bold>Clinical trial registration number:<\/jats:bold><jats:styled-content style=\"fixed-case\">UMIN000009096<\/jats:styled-content><\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12057","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T02:52:43Z","timestamp":1395370363000},"page":"93-98","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Duloxetine on Urethral Resting Pressure and on Sphincter Contractility in Response to Coughing and Magnetic Stimulation in Healthy Women"],"prefix":"10.1111","volume":"7","author":[{"given":"Makoto","family":"YONO","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Nishi\u2010Kumamoto Hospital, Medical Co. LTA Kumamoto Japan"},{"name":"Department of Urology Nishi\u2010Kumamoto Hospital, Medical Co. LTA Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"OTANI","sequence":"additional","affiliation":[{"name":"Department of Urology Nishi\u2010Kumamoto Hospital, Medical Co. LTA Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"ITO","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Sumida Hospital, Medical Co. LTA Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"INOUE","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Nishi\u2010Kumamoto Hospital, Medical Co. 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LTA Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukikuni","family":"SAKATA","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Nishi\u2010Kumamoto Hospital, Medical Co. LTA Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"IRIE","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Nishi\u2010Kumamoto Hospital, Medical Co. 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