{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:50:09Z","timestamp":1790833809669,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T00:00:00Z","timestamp":1404691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["22591802"],"award-info":[{"award-number":["22591802"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the role of noradrenergic pathways in the urethral continence reflex during abdominal compression in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Under urethane anesthesia, urethral baseline pressure (<jats:styled-content style=\"fixed-case\">UBP<\/jats:styled-content>) and urethral pressure response (<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>) during momentary abdominal compression using a 100 g weight was measured using a transurethral microtransducer\u2010tipped catheter placed at the middle urethra in Sprague\u2013Dawley female rats. Following intravenous (i.v.) application of hexamethonium or<jats:italic>\u03b1<\/jats:italic>\u2010bungarotoxin to block urethral smooth or striated muscle function, respectively, the effects of terazosin, an<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>\u2010adrenoceptor (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) antagonist (0.3 mg\/kg, i.v.), medetomidine, an<jats:italic>\u03b1<\/jats:italic><jats:sub>2<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>agonist (0.3 mg\/kg, i.v.) or nisoxetine, a norepinephrine reuptake inhibitor (1 mg\/kg, i.v.) followed by terazosin on<jats:styled-content style=\"fixed-case\">UBP<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After hexamethonium pretreatment, terazosin did not alter<jats:styled-content style=\"fixed-case\">UBP<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>, whereas medetomidine significantly decreased<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>by 28% without<jats:styled-content style=\"fixed-case\">UBP<\/jats:styled-content>changes. Nisoxetine significantly increased<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>by 64%, which was eliminated by terazosin, but<jats:styled-content style=\"fixed-case\">UBP<\/jats:styled-content>was not altered by nisoxetine. After<jats:italic>\u03b1<\/jats:italic>\u2010bungarotoxin pretreatment,<jats:styled-content style=\"fixed-case\">UBP<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>were significantly decreased by terazosin or medetomidine. Nisoxetine induced significant increases in<jats:styled-content style=\"fixed-case\">UBP<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>by 16 and 15%, respectively, which were antagonized by terazosin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that: the baseline activity and reflex contraction of urethral smooth muscle are decreased by<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>inhibition or<jats:italic>\u03b1<\/jats:italic><jats:sub>2<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>stimulation; the reflex contraction of urethral striated muscle is decreased by<jats:italic>\u03b1<\/jats:italic><jats:sub>2<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>stimulation, but not by<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>inhibition; and nisoxetine increases baseline and reflex activity of smooth muscle in addition to striated muscle reflex activity by<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>stimulation. These findings will be useful to understand nerve\u2010mediated urethral closure mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12065","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T14:43:53Z","timestamp":1404744233000},"page":"155-161","source":"Crossref","is-referenced-by-count":4,"title":["Noradrenergic Mechanisms Controlling Urethral Smooth and Striated Muscle Function in Urethral Continence Reflex in Rats"],"prefix":"10.1111","volume":"7","author":[{"given":"Akira","family":"FURUTA","sequence":"first","affiliation":[{"name":"Department of Urology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"SUZUKI","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Rehabilitation Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouji","family":"KIMURA","sequence":"additional","affiliation":[{"name":"Department of Urology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"ASANO","sequence":"additional","affiliation":[{"name":"Department of Urology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"EGAWA","sequence":"additional","affiliation":[{"name":"Department of Urology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"YOSHIMURA","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)67925-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200109000-00007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6777(2001)20:1<43::AID-NAU6>3.0.CO;2-F"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012213432501"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S0022-3565(25)10548-X","article-title":"Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose\u2010anesthetized female cat","volume":"274","author":"Thor KB","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15378.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67591-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00226.2006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0022-3565(25)10634-4","article-title":"Pharmacological analysis of the noradrenergic control of central sympathetic and somatic reflexes controlling the lower urinary tract in the anesthetized cat","volume":"274","author":"Danuser H","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.2012.16.1.47"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20888"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00010.2003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.07.139"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00038.2004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90241.2008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)51425-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1403-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.11.008"},{"key":"e_1_2_7_20_1","first-page":"873","article-title":"Autonomic innervation of the muscles in the wall of the bladder and proximal urethra of male rats","volume":"128","author":"Watanabe H","year":"1979","journal-title":"J Anat"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00443.2006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00780.2005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0022-3565(24)29214-4","article-title":"alpha2A\u2010adrenoceptor stimulation reduces capsaicin\u2010induced glutamate release from spinal cord synaptosomes","volume":"299","author":"Li X","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200303000-00016"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01549-7"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.04.028"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000296076.04510.e1"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12065","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T17:58:43Z","timestamp":1746295123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,7]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/luts.12065"],"URL":"https:\/\/doi.org\/10.1111\/luts.12065","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,7]]}}}