{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:35:17Z","timestamp":1776818117616,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Objective<\/jats:title>To analyze the video\u2010urodynamic results of voiding dysfunction in men of all ages with bothersome lower urinary tract symptoms (LUTS<\/jats:styled-content>) after \u03b1\u20101 adrenoceptor blocker therapy.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 930 consecutive men over 45 years of age with LUTS<\/jats:styled-content> who were failure treated with \u03b1\u20101 blocker therapy for at least one month were retrospectively studied. Patients underwent video\u2010urodynamic studies to evaluate the cause of lower urinary tract dysfunction (LUTD<\/jats:styled-content>). Clinical symptoms, prostatic measurements, and video\u2010urodynamic findings were compared among different LUTD<\/jats:styled-content> groups.<\/jats:p><\/jats:sec>Results<\/jats:title>After video\u2010urodynamic studies, 653 (70.2%) men were diagnosed with voiding dysfunction and 277 (29.8%) were with bladder dysfunction. Among patients with voiding dysfunction, bladder neck dysfunction (BND<\/jats:styled-content>) occurred in 242 (37.1%), benign prostatic obstruction (BPO<\/jats:styled-content>) in 298 (45.6%), and poor relaxation of the external sphincter (PRES<\/jats:styled-content>) in 113 (17.3%). The symptom score did not differ significantly among the three subgroups. The mean age, total prostate volume (TPV<\/jats:styled-content>), transition zone index, and prostate\u2010specific antigen were also significantly higher in BPO<\/jats:styled-content> patients compared with the other two subgroups, but no difference was noted between BND<\/jats:styled-content> and PRES<\/jats:styled-content> patients. BPO<\/jats:styled-content> patients had significantly higher voiding pressure, higher Abrams\u2010Griffiths number, lower Qmax, and a higher rate of detrusor overactivity than did patients in the other two subgroups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Bladder neck dysfunction and PRES<\/jats:styled-content> play important roles in male LUTS<\/jats:styled-content>. In men younger than 70 years with small TPV<\/jats:styled-content> and persistent LUTS<\/jats:styled-content> after \u03b1\u20101 blocker therapy, video\u2010urodynamic studies should be performed to make an accurate diagnosis before invasive surgery is planned.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12067","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T06:13:24Z","timestamp":1404972804000},"page":"143-148","source":"Crossref","is-referenced-by-count":13,"title":["Role of Bladder Neck and Urethral Sphincter Dysfunction in Men with Persistent Bothersome Lower Urinary Tract Symptoms after \u03b1\u20101 Blocker Treatment"],"prefix":"10.1111","volume":"7","author":[{"given":"Qian\u2010Sheng","family":"KE","sequence":"first","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital, Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Hong","family":"JIANG","sequence":"additional","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital, Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hann\u2010Chorng","family":"KUO","sequence":"additional","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital, Tzu Chi University Hualien 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