{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:41Z","timestamp":1787015741269,"version":"build-2736575974"},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T00:00:00Z","timestamp":1407974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>\n                    Based on evidence from available literature, we review the pathophysiology of detrusor underactivity (\n                    <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                    ).\n                    <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                    is likely to be multifactorial. Aging reduces detrusor activity, but other concomitant causes may aggravate this condition, resulting in decrease of detrusor contractility. Impaired detrusor contractility has been regarded as a major etiologic factor of\n                    <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                    . However, a more complex pathology has been proposed. As contributing factors to\n                    <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                    , we discuss disturbances of the sensory afferent side of the micturition reflex, the central nervous system (\n                    <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>\n                    ) and the efferent side of the reflex, including nerves and the detrusor muscle. Particularly, dysfunction of afferent nerves in the bladder and urethra may play a crucial role in the pathogenesis of\n                    <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                    . In addition, recent studies suggest that chronic bladder ischemia and resultant oxidative stress cause detrusor overactivity progressing to\n                    <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>\n                    and inability to empty the bladder.\n                  <\/jats:p>","DOI":"10.1111\/luts.12070","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T10:01:20Z","timestamp":1408010480000},"page":"131-137","source":"Crossref","is-referenced-by-count":29,"title":["Detrusor Underactivity: The Current Concept of the Pathophysiology"],"prefix":"10.1111","volume":"6","author":[{"given":"Masaki","family":"YOSHIDA","sequence":"first","affiliation":[{"name":"Department of Urology National Center for Geriatrics and Gerontology Obu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"YAMAGUCHI","sequence":"additional","affiliation":[{"name":"Division of Bioengineering and LUTD Research Nihon University College of Engineering Kohriyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02243-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-009-0055-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20765"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00917.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.11.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1001\/jama.1987.03390220074024","article-title":"Detrusor hyperactivity with impaired contractile function. An unrecognized by common cause of incontinence in elderly patients","volume":"257","author":"Resnick NM","year":"1987","journal-title":"J Am Med Assoc"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(1998)17:6<621::AID-NAU6>3.0.CO;2-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36619-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35867-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35868-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35869-X"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000055781.07630.aa"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-2-301"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04092.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36782-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199501000-00082"},{"key":"e_1_2_8_18_1","first-page":"587","article-title":"Contractility of the guinea pig bladder measured in situ and in vitro","volume":"13","author":"Groen J","year":"1994","journal-title":"Br J Urol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1986.tb09089.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)44930-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-009-0055-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00175-3"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706147"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-005-1084-0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0022-3565(25)13030-9","article-title":"Autonomic receptors in urinary tract: sex and age differences","volume":"253","author":"Latifpour J","year":"1990","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67508-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0022-3565(25)24722-X","article-title":"Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra","volume":"257","author":"Yoshida M","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90769-E"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40634-3"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)44928-7"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282247"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37955-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00616-X"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11300.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11793.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)00185-X"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10115"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1540\/jsmr.41.117"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.1.111"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000177450.34451.97"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.061"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000049644.27713.c8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10042"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706604"},{"key":"e_1_2_8_45_1","first-page":"9","article-title":"A urethral afferent mediated excitatory bladder reflex exists in humans","volume":"360","author":"Gustafson KJ","year":"2004","journal-title":"Neuroscience"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20487"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00613.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.09.021"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002400000135"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.10.060"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-8206.2003.00187.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04667.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04624.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04626.x"},{"key":"e_1_2_8_55_1","volume-title":"Hazzard's Principles of Geriatric Medicine and Gerontology","author":"Kuchel GA","year":"2009"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.5.R1473"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-004-0416-8"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0599t.x"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.08.125"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06525.x"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2009.07.002"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.01.031"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68236-5"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68995-1"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20843"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1757-5672.2011.00138.x"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21073"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.10.097"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22517"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000048668.97821.f4"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.096"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21191"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12070","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T01:43:05Z","timestamp":1746322985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,14]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/luts.12070"],"URL":"https:\/\/doi.org\/10.1111\/luts.12070","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,14]]}}}