{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T13:18:37Z","timestamp":1776604717615,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T00:00:00Z","timestamp":1415232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated the effect of the selective prostaglandin <jats:styled-content style=\"fixed-case\">E<jats:sub>2<\/jats:sub> EP2<\/jats:styled-content> receptor agonist <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010533,536 on voiding efficiency in rats with midodrine\u2010induced functional urethral obstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The effect of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010533,536 (0.03\u20130.3 mg\/kg, intravenous [i.v.]) on urethral perfusion pressure (<jats:styled-content style=\"fixed-case\">UPP<\/jats:styled-content>) was investigated in anesthetized rats pre\u2010treated with midodrine (1 mg\/kg, i.v.), which forms an active metabolite that acts as an \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor agonist. The effect of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010533,536 (0.03\u20130.3 mg\/kg, i.v.) on cystometric parameters was also investigated in anesthetized rats. In addition, the effect of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010533,536 (0.03\u20130.3 mg\/kg, i.v.) on residual urine volume (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) and voiding efficiency (<jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>) was investigated in conscious rats treated with midodrine (1 mg\/kg, i.v.).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010533,536 dose\u2010dependently decreased <jats:styled-content style=\"fixed-case\">UPP<\/jats:styled-content> elevated by midodrine in anesthetized rats. In contrast, <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010533,536 did not affect maximum voiding pressure, intercontraction interval, or intravesical threshold pressure. In conscious rats, midodrine (1 mg\/kg, i.v.) markedly increased <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> and reduced <jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\u2010533,536 dose\u2010dependently ameliorated increases in <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> and decreases in <jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content> induced by midodrine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that a selective <jats:styled-content style=\"fixed-case\">EP2<\/jats:styled-content> receptor agonist could ameliorate the elevation of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> and improve the reduction of <jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content> in rats with functional urethral obstruction caused by stimulation of \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptors. The mechanism of action might be not potentiation of bladder contraction but rather preferential relief of urethral constriction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12080","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T10:43:11Z","timestamp":1415270591000},"page":"130-135","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Selective Prostaglandin <scp>E<sub>2<\/sub> EP2<\/scp> Receptor Agonist <scp>CP<\/scp>\u2010533,536 on Voiding Efficiency in Rats with Midodrine\u2010Induced Functional Urethral Obstruction"],"prefix":"10.1111","volume":"8","author":[{"given":"Ryoko","family":"KURIHARA","sequence":"first","affiliation":[{"name":"Pharmacology Research Laboratories Drug Discovery Research, Astellas Pharma Inc.  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"IMAZUMI","sequence":"additional","affiliation":[{"name":"Pharmacology Research Laboratories Drug Discovery Research, Astellas Pharma Inc.  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"TAKAMATSU","sequence":"additional","affiliation":[{"name":"Pharmacology Research Laboratories Drug Discovery Research, Astellas Pharma Inc.  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"ISHIZU","sequence":"additional","affiliation":[{"name":"Pharmacology Research Laboratories Drug Discovery Research, Astellas Pharma Inc.  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiji","family":"YOSHINO","sequence":"additional","affiliation":[{"name":"Pharmacology Research Laboratories Drug Discovery Research, Astellas Pharma Inc.  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