{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:47:45Z","timestamp":1773215265195,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["107619"],"award-info":[{"award-number":["107619"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Objectives<\/jats:title>To investigate the change of bladder wall hypertrophy to relieve bladder outlet obstruction (BOO<\/jats:styled-content>) by treatment with 5\u03b1\u2010reductase inhibitor.<\/jats:p><\/jats:sec>Methods<\/jats:title>Men who have BOO<\/jats:styled-content> confirmed by urodynamic study (BOO<\/jats:styled-content> index \u226540) were treated with dutasteride 0.5\u2009mg once a day for 6\u2009months. We measured ultrasound estimated bladder weight (UEBW<\/jats:styled-content>), UEBW<\/jats:styled-content> divided by body surface area (UEBW<\/jats:styled-content>\/BSA<\/jats:styled-content>), and bladder wall thickness (BWT<\/jats:styled-content>) before and after treatment. Changes in LUTS<\/jats:styled-content> parameters were assessed by using the I<\/jats:styled-content>nternational P<\/jats:styled-content>rostate S<\/jats:styled-content>ymptom S<\/jats:styled-content>core, uroflowmetry, residual urine volume, prostate volume, serum prostate\u2010specific antigen (PSA<\/jats:styled-content>), and LUTS<\/jats:styled-content> outcome scores (LOS<\/jats:styled-content>). Correlation between the change of LUTS<\/jats:styled-content> parameters and UEBW<\/jats:styled-content>, UEBW<\/jats:styled-content>\/BSA<\/jats:styled-content>, and BWT<\/jats:styled-content> were evaluated. We assessed the changes of bladder wall hypertrophy according to the results of benefit, satisfaction, and willingness to continue (BSW<\/jats:styled-content>) questionnaire.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty patients completed the 6\u2010month study. The mean UEBW<\/jats:styled-content> was 47.10\u2009\u00b1\u20097.79\u2009g before and 50.07\u2009\u00b1\u20095.39\u2009g after dutasteride treatment (P<\/jats:italic>\u2009=\u20090.259). The mean UEBW<\/jats:styled-content>\/BSA<\/jats:styled-content> was 26.47\u2009\u00b1\u20094.30\u2009g\/m2<\/jats:sup> before and 28.2\u2009\u00b1\u20093.53\u2009g\/m2<\/jats:sup> after treatment (P<\/jats:italic>\u2009=\u20090.253), and there was no definite change in mean BWT<\/jats:styled-content> after treatment (P<\/jats:italic>\u2009=\u20090.301). Most LUTS<\/jats:styled-content> parameters including LOS<\/jats:styled-content> significantly improved. Increased BOO<\/jats:styled-content> index value was related to decreased BWT<\/jats:styled-content> (\u03c1\u2009=\u20090.361, P<\/jats:italic>\u2009=\u20090.049). There was no definite change in mean UEBW<\/jats:styled-content>, UEBW<\/jats:styled-content>\/BSA<\/jats:styled-content>, and BWT<\/jats:styled-content> according to the results of the BSW<\/jats:styled-content> questionnaire.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There was no change in UEBW<\/jats:styled-content>, UEBW<\/jats:styled-content>\/BSA<\/jats:styled-content> and BWT<\/jats:styled-content> despite improving most clinical parameters suggesting BOO<\/jats:styled-content>. The changes of bladder wall hypertrophy parameters still have limitations to directly reflect the relief of BOO<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12110","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T09:36:00Z","timestamp":1437989760000},"page":"67-74","source":"Crossref","is-referenced-by-count":4,"title":["Change of Ultrasound Estimated Bladder Weight and Bladder Wall Thickness After Treatment of Bladder Outlet Obstruction With Dutasteride"],"prefix":"10.1111","volume":"9","author":[{"given":"Ha Na","family":"LEE","sequence":"first","affiliation":[{"name":"Department of Urology Seoul Seonam Hospital, Ewha Womans University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Suk","family":"LEE","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Changwon Hospital, Sungkyunkwan University School of Medicine Changwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deok Hyun","family":"HAN","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu\u2010Sung","family":"LEE","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Korea"},{"name":"Department of Medical Device Management and Research SAIHST, Sungkyunkwan University, Seoul 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