{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:28:17Z","timestamp":1773923297444,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T00:00:00Z","timestamp":1443225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010740","name":"Asahi Kasei Pharma Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010740","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The effect of naftopidil on symptoms of tranilast\u2010induced interstitial cystitis (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>) was examined in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two female rats were divided into four groups (control, naftopidil, tranilast, and combination groups). Rats in the control group were fed a standard diet, while rats in the naftopidil, tranilast, and combination groups were fed diets containing naftopidil, tranilast, or naftopidil\u2009+\u2009tranilast, respectively. After 4\u2009weeks of treatment, locomotor activity was measured and continuous cystometry was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the light period, locomotor activity was lower in the tranilast group than in the control, naftopidil, and combination groups. During the dark period, locomotor activity was higher in the naftopidil group than in the other three groups. The combination group showed higher locomotor activity than the tranilast group, but significantly lower activity than the naftopidil group. Continuous cystometry revealed that the interval between bladder contractions was shorter in the tranilast group than in the other three groups. The combination group also had a shorter interval between contractions than the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Naftopidil improved the symptoms of tranilast\u2010induced <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>, such as reduced locomotor activity due to pelvic pain and a shortened interval between bladder contractions. Therefore, naftopidil may be a potential treatment for <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12113","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T09:36:50Z","timestamp":1443260210000},"page":"107-110","source":"Crossref","is-referenced-by-count":5,"title":["Naftopidil Improves Symptoms in a Rat Model of Tranilast\u2010Induced Interstitial Cystitis"],"prefix":"10.1111","volume":"9","author":[{"given":"Kimio","family":"SUGAYA","sequence":"first","affiliation":[{"name":"Southern Knights' Laboratory LLP  Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"NISHIJIMA","sequence":"additional","affiliation":[{"name":"Southern Knights' Laboratory LLP  Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"KADEKAWA","sequence":"additional","affiliation":[{"name":"Southern Knights' Laboratory LLP  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