{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T02:52:28Z","timestamp":1764211948046},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010740","name":"Asahi Kasei Pharma Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010740","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of naftopidil on bladder capillary blood flow using bladder outlet obstruction model rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2013<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats were divided into three groups: control group, bladder\u2010outlet\u2010obstruction group, and bladder\u2010outlet\u2010obstruction\u2009+\u2009naftopidil group. Bladder\u2010outlet\u2010obstruction surgery was performed in the bladder\u2010outlet\u2010obstruction and bladder\u2010outlet\u2010obstruction\u2009+\u2009naftopidil groups. The control group received sham\u2010operation. The bladder\u2010outlet\u2010obstruction\u2009+\u2009naftopidil group were treated with naftopidil (30\u2009mg\/kg) for 14\u2009days after bladder\u2010outlet\u2010obstruction operation, while the control and bladder\u2010outlet\u2010obstruction groups were treated with vehicle. Continuous cystometry was performed 14\u2009days after the surgery. Bladder blood flow was measured after 14\u2009days using a pencil lens charge\u2010coupled device microscopy system. The bladder was then harvested for histology and measuring 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine tissue level by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In cystometry, the bladder\u2010outlet\u2010obstruction rats showed bladder overactivity, while naftopidil treatment improved the cystometric pattern. The blood flow through the submucosal capillaries of the bladder base in the bladder\u2010outlet\u2010obstruction group was lesser than that in the control, whereas the bladder\u2010outlet\u2010obstruction\u2009+\u2009naftopidil group showed significantly greater blood flow than the bladder\u2010outlet\u2010obstruction group. The bladder tissue in the bladder\u2010outlet\u2010obstruction group showed a tendency to contain more hypertrophic detrusor muscle and inflammatory cells compared to those in the control group, while naftopidil treatment suppressed these histological changes. The 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine levels in the bladder tissue significantly differed among the three groups (the bladder\u2010outlet\u2010obstruction group\u2009&gt;\u2009the bladder\u2010outlet\u2010obstruction\u2009+\u2009naftopidil group\u2009&gt;\u2009the control group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Naftopidil improved bladder overactivity as well as the impaired bladder blood flow.caused by bladder\u2010outlet\u2010obstruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/luts.12119","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T17:03:51Z","timestamp":1446829431000},"page":"111-116","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Naftopidil on Bladder Microcirculation in a Rat Model of Bladder Outlet Obstruction"],"prefix":"10.1111","volume":"9","author":[{"given":"Tsuyoshi","family":"MAJIMA","sequence":"first","affiliation":[{"name":"Department of Urology 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