{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T11:23:08Z","timestamp":1788088988935,"version":"build-2803163510"},"reference-count":101,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LUTS"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Non\u2010neurogenic lower urinary tract dysfunction (<jats:styled-content style=\"fixed-case\">LUTD<\/jats:styled-content>) in children is very common in clinical practice and is important as an underlying cause of lower urinary tract symptoms, urinary tract infection and vesicoureteral reflux in affected children. <jats:styled-content style=\"fixed-case\">LUTD<\/jats:styled-content> in children is caused by multiple factors and might be related with a delay in functional maturation of the lower urinary tract. Behavioral and psychological problems often co\u2010exist in children with <jats:styled-content style=\"fixed-case\">LUTD<\/jats:styled-content> and bowel dysfunction. Recent findings in functional brain imaging suggest that bladder bowel dysfunction and behavioral and psychiatric disorders in children might share common pathophysiological factors in the brain. Children with suspected <jats:styled-content style=\"fixed-case\">LUTD<\/jats:styled-content> should be evaluated properly by detailed history taking, validated questionnaire on voiding and defecation, voiding and bowel diary, urinalysis, screening ultrasound, uroflowmetry and post\u2010void residual measurement. Invasive urodynamic study such as videourodynamics should be reserved for children in whom standard treatment fails. Initial treatment of non\u2010neurogenic <jats:styled-content style=\"fixed-case\">LUTD<\/jats:styled-content> is standard urotherapy comprising education of the child and family, regular optimal voiding regimens and bowel programs. Pelvic floor muscle awareness, biofeedback and neuromodulation can be used as a supplementary purpose. Antimuscarinics and \u03b1\u2010blockers are safely used for overactive bladder and dysfunctional voiding, respectively. For refractory cases, botulinum toxin A injection is a viable treatment option. Prudent use of urotherapy and pharmacotherapy for non\u2010neurogenic <jats:styled-content style=\"fixed-case\">LUTD<\/jats:styled-content> should have a better chance to cure various problems and improve self\u2010esteem and quality of life in affected children.<\/jats:p>","DOI":"10.1111\/luts.12123","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T11:22:44Z","timestamp":1448882564000},"page":"75-85","source":"Crossref","is-referenced-by-count":24,"title":["Pathophysiological and Therapeutic Considerations for Non\u2010Neurogenic Lower Urinary Tract Dysfunction in Children"],"prefix":"10.1111","volume":"8","author":[{"given":"Hidehiro","family":"KAKIZAKI","sequence":"first","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"KITA","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"WATANABE","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"WADA","sequence":"additional","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00416-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21195"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12694"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.92.s1.5.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000101907.87169.06"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2006.01217.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.06.063"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000091219.46560.7b"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.09.116"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/B978-1-4160-3204-5.00027-X","volume-title":"Pediatric Urology","author":"Yeung CK","year":"2010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65543-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68036-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000161216.45653.e3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2009.11.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1995.tb07278.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1995.tb07682.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1998.00544.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000019717"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1996.00106.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1997.00309.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66495-4"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66494-2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1998.00567.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68226-2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000108126.23417.17"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.08.048"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64455-0"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.07.011"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.01.110"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.05.014"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64290-5"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20753"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000177450.34451.97"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00324-1"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20549"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20740"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0894"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21205"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031023"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)45077-4"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(93)90623-I"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67239-4"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000152183.91888.f6"},{"key":"e_1_2_7_45_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000472809","article-title":"Relevance of constipation to enuresis, urinary tract infection and reflux","volume":"13","author":"Yazbeck S","year":"1987","journal-title":"Eur Urol"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62686-7"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.10.064"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21225"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.10.038"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67238-2"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67479-4"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65590-5"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.03.073"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21152"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.121"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2011.12.001"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.03.033"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.126"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22342"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.06.054"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.059"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2011.01.004"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2014.03.013"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.01.049"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.148"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2014.06.024"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.07.118"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.09.025"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65605-4"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65606-6"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64227-9"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000119961.58222.86"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.03.007"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.02.034"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.053"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21140"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)68067-4"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000085961.27403.4a"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000135735.49099.8c"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000157689.98314.69"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000179241.99381.5e"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.10.032"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.132"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.05.076"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02152.x"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000147813.28822.d2"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000152322.17542.63"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.05.002"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.04.062"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.05.100"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2012.02.008"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.11.060"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2002.02778.x"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2009.01.005"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.12.021"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2013.09.004"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00301-6"},{"key":"e_1_2_7_98_1","doi-asserted-by":"crossref","first-page":"119.e1\u20136","DOI":"10.1016\/j.jpurol.2014.10.006","article-title":"Breaking the vicious circle: onabotulinum toxin A in children with therapy\u2010refractory dysfunctional voiding","volume":"11","author":"\u2018t Hoen LA","year":"2015","journal-title":"J Pediatr Urol"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2005.07.004"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2011.12.005"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1159\/000052236"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.07.012"}],"container-title":["LUTS: Lower Urinary Tract Symptoms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fluts.12123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/luts.12123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T14:19:45Z","timestamp":1696515585000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,30]]},"references-count":101,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/luts.12123"],"URL":"https:\/\/doi.org\/10.1111\/luts.12123","archive":["Portico"],"relation":{},"ISSN":["1757-5664","1757-5672"],"issn-type":[{"value":"1757-5664","type":"print"},{"value":"1757-5672","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,30]]}}}